Projects per year
Organization profile
Organization profile
The PhD Program in Cell Biology and Biomedicine is based on the growing need for human capital capable of interrelating and integrating basic knowledge about the functioning of the cell and its molecules and the human diseases that require better treatments. One of the main reasons that make Cell Biology a fundamental discipline for the development of Biomedicine is that most diseases arise from alterations in some cellular function, where most treatments attempt to restore or inhibit that function. Thus, an advance in the detailed knowledge of cellular functioning is required, especially in certain aspects that are still not well understood and that can only be elucidated with experimental research.
The Program brings together a diverse group of consolidated researchers, incorporating an interdisciplinary approach, such as aspects of structural, molecular, evolutionary, and computational biology. The objective of the Program is the formation of human capital, capable of performing independent research of excellence, which contributes to the knowledge of the normal and pathological functioning of the cell as a rational search for innovative therapeutic alternatives, in tune with the current requirements of society and the prevalent pathologies in the country.
This program has large institutional laboratory areas with modern designs for experimental research, integrating the student to a wide network of collaborations and exchange opportunities with laboratories of prestigious national and international institutions.
The Program is aimed at graduates and Masters in Biology, Medicine, Chemistry, Biochemistry and Biotechnology or equivalent training.
The lines and sublines of research of the Program are:
- Protein and membrane trafficking: mechanisms, functions and disease:
- Endocytic, exocytic and secretory pathways (conventional and non-conventional), and mechanisms of cell polarity.
- Role of organelles and their intra-membrane interactions in cell plasticity, signaling and metabolism.
- Membranous vehicles (microvesicles and exosomes) in cell communication and their importance in cancer and obesity.
- Structural and evolutionary bases of protein and membrane trafficking mechanisms.
- Pathologies associated with autoantibodies, inflammation, metabolism and/or aging.
- Neuronal dysfunction due to autoantibodies and neuropathologies, potential therapeutic targets.
- Function and dysfunction of organelles and macromolecules in aging, inflammatory and metabolic pathologies, including the involvement of genome-environment interaction (epigenetics).
- Molecular, cellular and evolutionary mechanisms of inflammation and muscular dystrophies.
- Intercellular communications in microenvironments and their contribution to metabolism.
- Homeostasis, recycling and cellular plasticity: mechanisms and disease.
- Autophagocytosis as a process of adaptation, recycling, cellular turnover and survival, alterations and therapeutic potential in cancer, autoimmunity, obesity and aging.
- Proteasome and ubiquitination in quality control and degradation of normal and abnormal proteins.
- Regulation of cellular plasticity processes and their molecular alterations in the development of pathologies.
- Formation and regulation of biomolecular condensates by liquid-liquid phase separation and their role in cellular plasticity.
- Cellular basis of cellular plasticity under hypoxic conditions.
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Collaborations and top research areas from the last five years
Profiles
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Raul René Araya Secchi, PhD
- Universidad San Sebastián - Investigador
- Facultad de Ingeniería, Arquitectura y Diseño - Investigador
- Magíster en Biomedicina Molecular - Investigador
- Doctorado en Ingeniería - Investigador
- Doctorado en Biología Computacional - Investigador
- Doctorado en Biología Celular y Biomedicina - Investigador
- Sede Santiago - Investigador
Person: Researcher
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Enrique Hector Brandan Siques, PhD
- Universidad San Sebastián - Investigador
- Facultad de Medicina y Ciencia - Investigador
- Doctorado en Biotecnología y Bioemprendimiento - Investigador
- Doctorado en Biología Celular y Biomedicina - Investigador
- Fundación Ciencia para la Vida - Investigador
- Sede Santiago - Investigador
Person: Researcher
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Patricia Verónica Burgos Hitschfeld, PhD
- Universidad San Sebastián - Investigador
- Facultad de Medicina y Ciencia - Investigador
- Magíster en Biomedicina Molecular - Investigador
- Doctorado en Biología Celular y Biomedicina - Director
- Centro de Biología Celular y Biomedicina - Investigador
- Sede Santiago - Investigador
Person: Researcher
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PCI-FOVI240189: Vinculación Internacional para Determinar el Rol de las Células Inmunes en la Fibrosis Cardiorrenal
Amador Carrasco, C. A. (PI), Leiva Mendoza, A. A. (CoI), Araos Salas, P. A. (CoI) & De Miguel, C. (CoI)
19/11/24 → 18/11/25
Project: REDES DE INVESTIGACIÓN INTERNACIONAL
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FONDECYT E-13240033: Primary Cilium-Derived Ectosomes: A Novel Mechanism for the Control of Inflammation in the Hypothalamus
Morselli, E. (PI), Varas Godoy, M. A. (Deputy director) & Criollo, A. (CoI)
03/11/24 → 02/11/28
Project: PROYECTO DE INVESTIGACIÓN
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PCI-FOVI240182: Desarrollo de nuevos biomarcadores y algoritmos para predicción de síndromes obstétricos: Chile-Singapur
Illanes, S. E. (PI) & Leiva Mendoza, A. A. (CoI)
17/10/24 → 16/10/25
Project: REDES DE INVESTIGACIÓN INTERNACIONAL
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Aging Microglia and Their Impact in the Nervous System
Jaime Eugenin, 2024, Microglia: Physiology, Pathophysiology and Therapeutic Potential. 1 ed. Suiza: Springer Nature, Vol. 37. p. 379-395 17 p. (Advances in Neurobiology; vol. 37).Translated title of the contribution :Aging Microglia and Their Impact in the Nervous System Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
3 Scopus citations -
AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter
Tavares, L. A., Rodrigues, R. L., Santos da Costa, C., Nascimento, J. A., Vargas de Carvalho, J., Nogueira de Carvalho, A., Mardones, G. A. & daSilva, L. L. P., 2024, In: Journal of Biological Chemistry. 300, 3, 105700.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A single bout of resistance exercise triggers mitophagy, potentially involving the ejection of mitochondria in human skeletal muscle
Díaz-Castro, F., Tuñón-Suárez, M., Rivera, P., Botella, J., Cancino, J., Figueroa, A. M., Gutiérrez, J., Cantin, C., Deldicque, L., Zbinden-Foncea, H., Nielsen, J., Henríquez-Olguín, C., Morselli, E. & Castro-Sepúlveda, M., 2024, In: Acta Physiologica. 240, 9, e14203.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
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Neuroendocrine Techniques at the Cutting Edge
Kerr Fuentes, B. D. (Organizer), Belsham, D. (Organizer), Lehman, M. (Organizer), Marshall, C. (Organizer), Evans, N. (Organizer) & Navarro, V. (Organizer)
2023 → 2023Activity: Participating in or organizing an event › Organizing a conference, workshop, ...
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Neuroendocrine Integration of Appetite and Metabolism
Kerr Fuentes, B. D. (Organizer), Navarro, V. (Participant), Scherer, P. E. (Participant), Matus Montero, M. S. (Participant) & Lee Liu, D. N. (Participant)
2023 → 2023Activity: Participating in or organizing an event › Participating in a conference, workshop, ...
Press/Media
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Discutiendo el futuro de la biología: Dr. Roberto Mayor visita la USS
26/03/24
1 Media contribution
Press/Media
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Descentralizando la ciencia: Doctorado en Biología Celular y Biomedicina USS llega a sede Valdivia
25/03/24
2 Media contributions
Press/Media
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Colaboración y nuevos horizontes para la salud y la enfermedad en Science & Friendship 2023
22/11/23
1 Media contribution
Press/Media
Equipment
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Analizador de Imágenes Luminiscentes
Gutiérrez Pérez, J. A. (Manager), Leiva Mendoza, A. A. (Manager), Barrera Alvarado, M. J. (Manager), Contreras Duarte, S. D. L. M. (Manager), Yáñez Henríquez, M. J. (Manager), Morselli, E. (Manager), Chiarello Peñaranda, D. (Manager), Carrasco Wong, I. J. (Manager), Lagos Arevalo, C. F. (Manager), Amador Carrasco, C. A. (Manager) & Vio Lagos, C. (Manager)
Equipment/facility: Equipment
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Autoclave
Lagos Arevalo, C. F. (Operator), Chiarello Peñaranda, D. (Operator), Amador Carrasco, C. A. (Operator), Carrasco Wong, I. J. (Operator), Morselli, E. (Operator), Leiva Mendoza, A. A. (Operator), Barrera Alvarado, M. J. (Operator), Contreras Duarte, S. D. L. M. (Operator), Gutiérrez Pérez, J. A. (Operator), Yáñez Henríquez, M. J. (Operator), Soto Arriaza, M. A. (Operator) & Lee Liu, D. N. (Manager)
Equipment/facility: Equipment
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Campana de Extracción de Gases
Gutiérrez Pérez, J. A. (Operator), Leiva Mendoza, A. A. (Operator), Barrera Alvarado, M. J. (Operator), Contreras Duarte, S. D. L. M. (Operator), Carrasco Wong, I. J. (Operator), Yáñez Henríquez, M. J. (Operator), Soto Arriaza, M. A. (Operator), Chiarello Peñaranda, D. (Operator), Amador Carrasco, C. A. (Operator), Morselli, E. (Operator), Lagos Arevalo, C. F. (Operator), Lee Liu, D. N. (Operator) & Vio Lagos, C. (Manager)
Equipment/facility: Equipment