Manuel Alejandro Varas Godoy

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Manuel Alejandro Varas Godoy, PhD

Associate Professor

 https://orcid.org/0000-0001-5857-4793
    Calculated based on number of publications stored in Pure and citations from Scopus
    Calculated based on number of publications stored in Pure and citations from Scopus
    Calculated based on number of publications stored in Pure and citations from Scopus
    20062024

    Research activity per year

    Personal profile

    Research interests

    His research focuses on how the activation of different stimuli such as chemotherapy, hypoxia, inflammation, or diet could be regulating the cargo and/or secretion of extracellular vesicles/exosomes derived from tumor cells. In addition, he studies the ability of these extracellular vesicles/exosomes to transfer pro-tumorigenic properties to different cells of the tumor microenvironment to promote the process of tumor progression

    Personal profile

    Dr. Manuel Varas-Godoy is Biochemist of the Pontificia Universidad Católica de Valparaíso, and PhD in Biotechnology of the Universidad Andrés Bello. He performs his Postdoctoral fellow at the Karolinska Institute in Sweden. He began his professional career as an Assistant Professor at the Universidad de los Andes. He is currently an Associate Professor at the Faculty of Medicine and Science at the Universidad San Sebastián. He is member of the Fondecyt Biology 2 Study Group being currently its Director, and he is Vice-president of the Chilean Society for Cell Biology

    Teaching

    Dr. Manuel Varas-Godoy participates in the courses of Molecular and Genetic Biology, and Cell Biology for the Medicine career of the Universidad San Sebastián. In addition, he participates in the Genomics and Proteomic course of the biochemistry career. He is member of the cloister of the Doctoral Program in Cell Biology and Biomedicine and the Doctoral Program in Immunology and Microbiology at Universidad San Sebastián, in which he participates in various courses such as Cell Biology, and Biomedicine

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

    Education/Academic qualification

    PhD, Biotecnología, Universidad Andrés Bello

    … → 2012

    Bachelor, Licenciado en Bioquímica, Pontificia Universidad Católica de Valparaíso

    … → 2006

    Bachelor, Bioquímico, Pontificia Universidad Católica de Valparaíso

    … → 2006

    External positions

    Universidad de los Andes Chile

    2015 → 2016

    Instituto Karolinska, Estocolomo, Suecia

    2013 → 2015

    Keywords

    • R Medicine (General)

    Cargo USS

    • Investigador (a)

    Jerarquía Académica

    • Profesor Asociado

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    Collaborations and top research areas from the last five years

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    • Chemo‐small extracellular vesicles released in cisplatin‐resistance ovarian cancer cells are regulated by the lysosomal function

      Cerda-Troncoso, C., Grünenwald, F., Arias‐Muñoz, E., Cavieres, V. A., Caceres‐Verschae, A., Hernández, S., Gaete‐Ramírez, B., Álvarez‐Astudillo, F., Acuña, R. A., Ostrowski, M., Burgos, P. V. & Varas-Godoy, M., 2024, In: Journal of Extracellular Biology. 3, 6

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells

      Almarza, C., Villalobos-Nova, K., Toro, M. A., González, M., Niechi, I., Brown‑Brown, D. A., López-Muñoz, R. A., Silva-Pavez, E., Gaete-Ramírez, B., Varas-Godoy, M., Burzio, V. A., Jara, L., Aguayo, F. & Tapia, J. C., 2024, In: Biological Research. 57, 1, 74.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells

      Polanco, C. M., Cavieres, V. A., Galarza, A. J., Jara, C., Torres, A. K., Cancino, J., Varas-Godoy, M., Burgos, P. V., Tapia-Rojas, C. & Mardones, G. A., 2024, In: Cells. 13, 4, 316.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution

      Puttick, C., Jones, T. P., Leung, M. M., Galvez-Cancino, F., Liu, J., Varas-Godoy, M., Rowan, A., Pich, O., Martinez-Ruiz, C., Bentham, R., Dijkstra, K. K., Black, J. R. M., Rosenthal, R., Kanu, N., Litchfield, K., Salgado, R., Moore, D. A., Loo, P. V., Jamal-Hanjani, M. & Quezada, S. A. & 262 others, Cheyne, H., Khalil, M., Richardson, S., Cruickshank, T., Lim, E., Aerts, H. J. W. L., Kaufmann, T. L., Huska, M. R., Naidu, B., Wilson, G. A., Rosenthal, R., Rowan, A., Bailey, C., Lee, C., Colliver, E., Enfield, K. S. S., Hill, M. S., Angelova, M., Pich, O., Biswas, D., Puttick, C., Vendramin, R., Murphy, C., Zagorulya, M., Jones, T. P., Leung, M. M., McGranahan, N., Castignani, C., Cadieux, E. L., Kittel, J., Haase, K., Koh, K., Scott, R., Matharu, G., Shaw, J. A., Hackshaw, A., Pilotti, C., Leslie, R., Hacker, A.-M., Smith, S., Walker, A., Abbosh, C., Richard, C., Naceur-Lombardelli, C., Gimeno-Valiente, F., Thakkar, K., Sunderland, M. W., Sivakumar, M., Kanu, N., Usaite, I., Saghafinia, S., Veeriah, S., Vanloo, S., Mussa, B., Magala, M., Keene, E., Lim, E. L., Black, J. R. S., Bakir, M. A., Huebner, A., Grigoriadis, K., Karasaki, T., Frankell, A. M., Hiley, C. T., Ward, S., Harries, S., Lucas, O., Moore, D. A., Birkbak, N. J., Martínez-Ruiz, C., Thol, K., Bentham, R., Liu, W. K., Bunkum, A., Hessey, S., Forster, M. D., Lee, S. M., Jamal-Hanjani, M., Karagianni, D., Quezada, S. A., Bola, S. K., Litchfield, K., Swanton, C., Quesne, J. L., AbdulJabbar, K., Veiga, C., Zaccaria, S., Tugwood, J., Dive, C., Szallasi, Z., Diossy, M., Marafioti, T., Borg, E., Falzon, M., Khiroya, R., Loo, P. V., Peggs, K. S., Price, G., Royle, G., Collins-Fekete, C.-A., Papadatos-Pastos, D., Wilson, J., Ahmad, T., Benafif, S., Cave, J., Kerr, K. M., Watkins, T. B. K., Salgado, R., Procter, A. J., Ahmed, A., Taylor, M. N., Nair, A., Lawrence, D., Patrini, D., Lindsay, C. R., Blackhall, F. H., Summers, Y., Krebs, M. G., Nye, E., Stone, R. K., Zhang, H., Nicod, J., Kirk, A., Asif, M., Bilancia, R., Kostoulas, N., Whiteley, J., Thomas, M., Patel, A. J., Chuter, D., MacKenzie, M., Schwarz, R. F., Kidd, A., Fraioli, F., Ashford, P., Kaplar, Z., Demeulemeester, J., Wilson, C., Shackcloth, M. J., Janes, S. M., Navani, N., Thakrar, R. M., Leek, A., Hodgkinson, J. D., Totton, N., Paiva-Correia, A., Beck, S., Tanic, M., Dick, C., Robinson, L., Russell, P., Sousa, P. D., Jordan, S., Rice, A., Raubenheimer, H., Bhayani, H., Ambrose, L., Devaraj, A., Chavan, H., Begum, S., Buderi, S. I., Kaniu, D., Malima, M., Booth, S., Fernandes, N., Shah, P., Proli, C., Nicholson, A. G., Boleti, E., Hewish, M., Blyth, K. G., Lester, J. F., Chaturvedi, A., Oliveira, P., Brown, K. D., Carter, M., Magness, A., Weeden, C. E., Grönroos, E., Goldman, J., Escudero, M., Hobson, P., Boeing, S., Denner, T., Barbè, V., Lu, W.-T., Hill, W., Naito, Y., Ramsden, Z., Kassiotis, G., Noorani, I., Grapa, A., Alzetani, A., Yuan, Y., Pan, X., French, J., Gilbert, K., Dwornik, A., Karamani, A., Chain, B., Pearce, D. R., Gálvez-Cancino, F., Stavrou, G., Mastrokalos, G.-T., Lowe, H. L., Matos, I. G., Reading, J. L., Hartley, J. A., Selvaraju, K., Chen, K., Ensell, L., Shah, M., Litovchenko, M., Pawlik, P., Gamble, S., Ung, S. K. A., Spanswick, V., Wu, Y., Rane, J. K., Al-Sawaf, O., Chervova, O., Hoogenboom, E. M., Monk, F., Holding, J. W., Choudhary, J., Bhakhri, K., Gorman, P., Stephens, R. C. M., Pisciella, M. C., Bandula, S., Wong, Y. N. S., Osman, A., Sangha, M., Langman, G., Shackleford, H., Djearaman, M., Middleton, G., Chee, S., Georg, P., Bajaj, A., Nakas, A., Sodha-Ramdeen, A., Tufail, M., Scotland, M., Boyles, R., Rathinam, S., Marrone, D., Dulloo, S., Fennell, D. A., Danson, S., Smith, E., Fontaine, E., Granato, F., Novasio, J., Rammohan, K., Joseph, L., Bishop, P., Shah, R., Joshi, V., Crosbie, P., Swanton, C. & McGranahan, N., 2024, In: Nature Genetics.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

      MISEV Consortium, 2024, In: Journal of Extracellular Vesicles. 13, 2, e12404.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      884 Scopus citations
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