Projects per year
Personal profile
Research interests
During life, every organism is exposed to diverse stress stimuli. The adaptation capacity is critical to maintain the homeostasis and ensure survival. Under stress conditions, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. Her research is focuses in understanding the contribution of this signaling pathway, which is driven by four kinases that phosphorylates the eukaryotic translation initiation factor 2 alpha (eIF2a), to neurodegenerative process and aging. Using in vivo and in vitro models, she studies the consequences of targeting ISR components in aging and to open new therapeutic strategies for treating neurodegenerative diseases.
Personal profile
Dr. Soledad Matus completed her PhD in Biological Sciences at Pontificia Universidad Catolica de Chile. Then she performed a Postdoctoral Fellowship at Faculty of Medicine Universidad de Chile, working in stress response signaling pathways in Neurodegenerative Diseases. Then she joined the Fundación Ciencia & Vida, leading the laboratory of “Biology of Neurodegeneration”. Currently, she is an Associate Professor at “Universidad San Sebastián”, and the Deputy Director of “Centro BASAL Ciencia & Vida”.
Teaching
Dr. Soledad Matus teaches the mechanisms of Neurodegeneration and Stress Responses at Facultad de Medicina y Ciencia of Universidad San Sebastián in the Ph.D. program in Cellular Biology and Biomedicine. She is a member of the Advisory Committee of the Ph.D. Program.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
Dive into the research topics where María Soledad Matus Montero is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
-
FONDECYT R-1230334: “Unraveling the role of the Nutritional Sensor GCN2 as New Therapeutic Target in Amyotrophic Lateral Sclerosis"
Matus Montero, M. S. (PI)
13/03/23 → 31/03/27
Project: Research
-
FB210008: Centro Científico y Tecnológico de Excelencia Ciencia y Vida. Proyecto Basal FB210008. 2021-2025
Tischler, N. (PI), Brandan Siques, E. H. (PI), González De La Rosa, L. A. (PI), Bono Merino, M. R. (PI), Tapia Rojas, C. C. (PI), Perez Acle, T. O. (PI), Matus Montero, M. S. (PI), Loyola Pedevila, M. A. (PI), Quatrini Nyqvist, R. C. (PI), Lladser Caldera, Á. F. (PI), Pacheco Rivera, R. A. (PI) & Rosemblatt Silber, M. C. (PI)
01/10/21 → 31/10/25
Project: Research
-
The integrated stress response is activated in the salivary glands of Sjögren’s syndrome patients
Carvajal, P., Bahamondes, V., Jara, D., Castro, I., Matus, S., Aguilera, S., Molina, C., González, S., Hermoso, M., Barrera, M. J. & González, M. J., 2023, In: Frontiers in Medicine. 10, 1118703.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Vidal, R. L., Sepulveda, D., Troncoso-Escudero, P., Garcia-Huerta, P., Gonzalez, C., Plate, L., Jerez, C., Canovas, J., Rivera, C. A., Castillo, V., Cisternas, M., Leal, S., Martinez, A., Grandjean, J., Sonia, D., Lashuel, H. A., Martin, A. J. M., Latapiat, V., Matus, S. & Sardi, S. P. & 2 others, , 2021, In: Molecular Therapy. 29, 5, p. 1862-1882 21 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration
Martinez, N. W., Gómez, F. E. & Matus, S., 2021, In: Frontiers in Aging Neuroscience. 13, 638208.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: Implications in Sjögren's syndrome
Barrera, M. J., Aguilera, S., Castro, I., Matus, S., Carvajal, P., Molina, C., González, S., Jara, D., Hermoso, M. & González, M. J., 2021, In: Rheumatology (United Kingdom). 60, 4, p. 1951-1962 12 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Pandemia COVID 19: Guías y recomendaciones para el manejo del Paro Cardíaco en adultos en el pre-hospitalario y admisión de guardia. Medidas tendientes a incrementar la eficacia y reducir el riesgo del SARS-CoV-2 (COVID-19) durante la reanimación cardiopulmonar (RCP) en el entorno sanitario
Translated title of the contribution :COVID-19 pandemic: Guidelines and recommendations for the management of cardiac arrest in adults in prehospital and on-call admissions. Measures to increase the effectiveness and reduce the risk of SARS-CoV-2 (COVID-19) during cardiopulmonary resuscitation (CPR) in the healthcare setting Research output: Contribution to journal › Comment/debate
Activities
- 1 Participating in a conference, workshop, ...
-
Neuroendocrine Integration of Appetite and Metabolism
Kerr Fuentes, B. D. (Organizer), Navarro, V. (Participant), Scherer, P. E. (Participant), Matus Montero, M. S. (Participant) & Lee Liu, D. N. (Participant)
2023 → 2023Activity: Participating in or organizing an event › Participating in a conference, workshop, ...