Role of lipids in the control of autophagy and primary cilium signaling in neurons

María Paz Hernández-Cáceres, Daniela Pinto-Nuñez, Patricia Rivera, Paulina Burgos, Francisco Díaz-Castro, Alfredo Criollo, Maria Jose Yañez*, Eugenia Morselli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The brain is, after the adipose tissue, the organ with the greatest amount of lipids and diversity in their composition in the human body. In neurons, lipids are involved in signaling pathways controlling autophagy, a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium, a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development. A crosstalk between primary cilia and autophagy has been established; however, its role in the control of neuronal activity and homeostasis is barely known. In this review, we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in neurons. Then we review the recent literature about specific lipid subclasses in the regulation of autophagy, in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions, specifically focusing on neurons, an area of research that could have major implications in neurodevelopment, energy homeostasis, and neurodegeneration.

Original languageEnglish
Pages (from-to)264-271
Number of pages8
JournalNeural Regeneration Research
Issue number2
StatePublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 Wolters Kluwer Medknow Publications. All rights reserved.

ASJC Scopus subject areas

  • Developmental Neuroscience


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