Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
1973 …2023

Research activity per year

Personal profile

Research interests

Autoimmunity: The immune system protects the organism from harmful event and tolerates what is beneficial. Tolerance is generated in the thymus and autoimmune diseases occur when the immune system attacks our own organism. Our laboratory is trying to understand the mechanisms underlying autoimmune diseases – specifically Systemic Lupus Erythematosus. Using a mouse model of lupus we found that when mice become sick the thymus involutes, loosing its normal structure and undergoing an accumulation of B-lymphocytes. Our recent results show that treatment of mice with bacterial products, viral RNA analogs, or induction of lupus produces a phenomenon similar to thymic involution. Understanding the physiological role of this process in autoimmunity is the focus of this project. Immune System and Cancer: The immune system can recognize and eliminate tumor cells. Cytotoxic CD8+ T cells are among the most relevant cell population in charge of tumor destruction. However, cancer usually progresses despite the presence of these cells. Adenosine, a molecule found in the tumor microenvironment, reduces the cytotoxic potential of CD8+ T cells affecting current immunotherapies against cancer. Our aim is to determine the role of Adenosine in this process and how to improve cancer Immunotherapy.

Personal profile

Mario Rosemblatt is a Biochemist from University of Chile with a PhD from Wayne State University, USA. He held positions as Research Fellow in Medicine at Harvard Medical School and as Research Associate of the Association pour le Research contre le Cancer, Paris. He founded and was the first Director of the Career in Molecular Biotechnology Engineering at the University of Chile. Founding Partner and Executive Director of the Fundación Ciencia & Vida. With training in Immunology, at present he directs the PhD Program in Immunology and Microbiology at Universidad San Sebastián.


Dr. Rosemblatt is a well-known Chilean immunologist that specially enjoys teaching. He teaches a graduate Course in Advanced Immunology that not only explains the current developments and theories in the field but also highlights – through discussions of the current literature – an overview of the methods and approaches used in today’s immunology research. Student participation is accomplished though the discussion and interpretation of recent papers. Required of all first year students in the Immunology and Microbiology Program.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Wayne State University

… → 1973

Bachelor, Biochemist, Universidad de Chile

… → 1966

External positions

Universidad de Chile, Santiago, Chile

2008 → …

Universidad Nacional Andrés Bello, Santiago, Chile


Fundación Ciencia & Vida, Santiago, Chile

1997 → …

Facultad de Ciencias, Universidad de Chile, Santiago, Chile


Faculté des Sciences, Université de Paris VII, Paris, France

1990 → …

Association pour le Recherche sur le Cancer, Paris, France


Unidad de Inmunología Celular, INTA, Universidad de Chile, Santiago, Chile


Boston Biomedical Research Institute, Boston, MA, USA


Brown University, Providence, RI. USA


Harvard Medical School, Massachusetts General Hospital, Boston, MA. USA


Department of Chemistry, Wayne State University, Detroit, Mich. USA



  • QR180 Immunology


Dive into the research topics where Mario Cesar Rosemblatt Silber is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or