Resumen
γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A+ during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection.
Idioma original | Inglés |
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Número de artículo | e2210490120 |
Publicación | Proceedings of the National Academy of Sciences of the United States of America |
Volumen | 120 |
N.º | 1 |
DOI | |
Estado | Publicada - 2023 |
Nota bibliográfica
Publisher Copyright:© 2022 the Author(s).
Áreas temáticas de ASJC Scopus
- General