TY - JOUR
T1 - Effect of cellulose nanofibrils on vancomycin drug release from chitosan nanocomposite films
AU - Cabrera-Barjas, Gustavo
AU - Becherán, Liliam
AU - Valdés, Oscar
AU - Giordano, Ady
AU - Segura-del Río, Rodrigo
AU - Bravo-Arrepol, Gastón
AU - Durán-Lara, Esteban F.
AU - Cea, Juan
AU - Berg, Alex
AU - Castaños, Johana
AU - Rodríguez-Llamazares, Saddys
AU - Fuentes, Gastón
AU - Katsarov, Plamen
AU - Lukova, Paolina
AU - Delattre, Cédric
N1 - Funding Information:
In memory of our dear colleague and friend, Patricia Bernabé Galloway, Ph.D., who performed part of this research until COVID-19 took her life. The authors also acknowledge the finantial support of ANID grant PIA/APOYO CCTE AFB170007, ACE210016 (G.C-B.; S. R-L., A.B.); CIPA CONICYT Regional GORE BIO BIO R17A10003, ACE210016 (S.R.L.; G.C-B.); ANID BASAL FB210015 CENAMAD (G.C-B., A.B.); INNOVA ALTA TECNOLOGIA 19IAT-112022 (G.C-B., J.C., A.B.); CORFO 22CVID-206836 (S.R-L); ANID FONDECYT REGULAR 1221609 (G.C-B.) and 1210107 (O.V.). and to Fondequip EQM 190179 (R.S., G.C-B).
Funding Information:
This research was funded by ANID grant PIA/APOYO CCTE AFB170007, ACE210016 (G.C-B.; S. R-L., A.B.); CIPA CONICYT Regional GORE BIO BIO R17A10003, ACE210016 (S.R.L.; G.C-B.); ANID BASAL FB210015 CENAMAD (G.C-B., A.B.); INNOVA ALTA TECNOLOGIA 19IAT-112022 (G.C-B., J.C., A.B.); CORFO 22CVID-206836 (S.R-L); ANID FONDECYT REGULAR 1221609 (G.C-B.) and 1210107 (O.V.).
Funding Information:
This research was funded by ANID grant PIA/APOYO CCTE AFB170007 , ACE210016 (G.C-B.; S. R-L., A.B.); CIPA CONICYT Regional GORE BIO BIO R17A10003 , ACE210016 (S.R.L.; G.C-B.); ANID BASAL FB210015 CENAMAD (G.C-B., A.B.); INNOVA ALTA TECNOLOGIA 19IAT-112022 (G.C-B., J.C., A.B.); CORFO 22CVID-206836 (S.R-L); ANID FONDECYT REGULAR 1221609 (G.C-B.) and 1210107 (O.V.).
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/10/10
Y1 - 2023/10/10
N2 - Overuse of antibiotic drugs usually leads to the further development of resistance to targeted bacteria. In this context, a controlled release system could be a solution to achieve higher drug efficiency without overdosing and drug resistance. In this work, nanocomposite films based on chitosan (CHI) reinforced with cellulose nanofibrils (CNF) for antibiotic release were prepared and characterized. Several nanocomposite films containing vancomycin hydrochloride and different amounts of CNF (5, 10, and 20 wt%) were prepared by the solvent casting method. Spectroscopic (FTIR), thermal (TG), morphological (SEM), mechanical, and swelling analyses of the films were performed to study the effect of nanofibers content on the nanocomposite properties. A good dispersion of CNF and the model drug was observed in the CHI matrix. FTIR spectroscopy confirmed the interaction between the film components (CNF and CHI). Film swelling capacity decreased with an increase of CNF content in the film formulation, whereas stiffness and tensile strength of the film increased. In addition, vancomycin release at pH = 7.4 was studied, and it was observed that controlled slower release could be achieved by tuning the CNF content in the chitosan film. The results confirm that these films could be useful for pharmaceutical purposes where the controlled release of drugs is required.
AB - Overuse of antibiotic drugs usually leads to the further development of resistance to targeted bacteria. In this context, a controlled release system could be a solution to achieve higher drug efficiency without overdosing and drug resistance. In this work, nanocomposite films based on chitosan (CHI) reinforced with cellulose nanofibrils (CNF) for antibiotic release were prepared and characterized. Several nanocomposite films containing vancomycin hydrochloride and different amounts of CNF (5, 10, and 20 wt%) were prepared by the solvent casting method. Spectroscopic (FTIR), thermal (TG), morphological (SEM), mechanical, and swelling analyses of the films were performed to study the effect of nanofibers content on the nanocomposite properties. A good dispersion of CNF and the model drug was observed in the CHI matrix. FTIR spectroscopy confirmed the interaction between the film components (CNF and CHI). Film swelling capacity decreased with an increase of CNF content in the film formulation, whereas stiffness and tensile strength of the film increased. In addition, vancomycin release at pH = 7.4 was studied, and it was observed that controlled slower release could be achieved by tuning the CNF content in the chitosan film. The results confirm that these films could be useful for pharmaceutical purposes where the controlled release of drugs is required.
KW - Biopolymers
KW - Cellulose nanofibers
KW - Chitosan
KW - Drug release
KW - Nanobiocomposite
KW - Vancomycin
UR - http://www.scopus.com/inward/record.url?scp=85169788175&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2023.112371
DO - 10.1016/j.eurpolymj.2023.112371
M3 - Article
AN - SCOPUS:85169788175
SN - 0014-3057
VL - 197
JO - European Polymer Journal
JF - European Polymer Journal
M1 - 112371
ER -