Resumen
Neuroinflammation is a common event in degenerative diseases of the central and peripheral nervous system, triggered by alterations in the immune system or inflammatory cascade. The pathophysiology of these disorders is multifactorial, whereby the therapy available has low clinical efficacy. This review propounds the relationship between the deregulation of T helper cells and hypoxia, mainly Th17 and HIF-1α molecular pathways, events that are involved in the occurrence of the neuroinflammation. The clinical expression of neuroinflammation is included in prevalent pathologies such as multiple sclerosis, Guillain–Barré syndrome, and Alzheimer’s disease, among others. In addition, therapeutic targets are analyzed in relation to the pathways that induced neuroinflammation.
Idioma original | Inglés |
---|---|
Número de artículo | 3073 |
Publicación | International Journal of Molecular Sciences |
Volumen | 24 |
N.º | 4 |
DOI | |
Estado | Publicada - 2023 |
Nota bibliográfica
Publisher Copyright:© 2023 by the authors.
Áreas temáticas de ASJC Scopus
- Catálisis
- Biología molecular
- Espectroscopia
- Informática aplicada
- Química física y teórica
- Química orgánica
- Química inorgánica