TY - JOUR
T1 - Preparation of Novel Electrospun Organic–Inorganic Hybrid Nanofibers Based on Polycaprolactone, Glycine Betaine, and Calcium Carbonate (P/G/CaCO3-EPnF)
AU - Butto-Miranda, Nicole
AU - Cabrera-Barjas, Gustavo
AU - Ibáñez, Andrés
AU - Neira-Carrillo, Andrónico
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/4
Y1 - 2023/4
N2 - Biomedicine requires materials able to respond to specific needs without affecting the organism. Organic–inorganic fibrillar polymeric matrices possess unique properties that may fulfill these needs. In the present study, different topology-controlled poly(ε-caprolactone)-based fibrillar matrices containing glycine betaine at varying concentrations (0.5, 1, and 2% w/v) were prepared via electrospinning. The matrices were used as substrates in calcium carbonate crystallization assays with gas diffusion to obtain a single organic–inorganic hybrid material. The resulting matrices and crystalline material were characterized using spectroscopic, microscopic, and thermogravimetric analyses. The incorporation of glycine betaine into a poly(ε-caprolactone) mesh modified the diameter of the fibers, without affecting the thermal behavior of the matrices. However, the chemical and morphological characteristics of the matrices did influence in vitro inorganic mineralization. The thermogravimetric analysis of the matrices, performed after the mineralization tests, demonstrated the existence of a new organic–inorganic hybrid material with unique properties, which is discussed in the present study.
AB - Biomedicine requires materials able to respond to specific needs without affecting the organism. Organic–inorganic fibrillar polymeric matrices possess unique properties that may fulfill these needs. In the present study, different topology-controlled poly(ε-caprolactone)-based fibrillar matrices containing glycine betaine at varying concentrations (0.5, 1, and 2% w/v) were prepared via electrospinning. The matrices were used as substrates in calcium carbonate crystallization assays with gas diffusion to obtain a single organic–inorganic hybrid material. The resulting matrices and crystalline material were characterized using spectroscopic, microscopic, and thermogravimetric analyses. The incorporation of glycine betaine into a poly(ε-caprolactone) mesh modified the diameter of the fibers, without affecting the thermal behavior of the matrices. However, the chemical and morphological characteristics of the matrices did influence in vitro inorganic mineralization. The thermogravimetric analysis of the matrices, performed after the mineralization tests, demonstrated the existence of a new organic–inorganic hybrid material with unique properties, which is discussed in the present study.
KW - calcium carbonate
KW - electrospinning
KW - glycine betaine
KW - hybrid materials
KW - organic–inorganic nanofibers
KW - polycaprolactone
UR - http://www.scopus.com/inward/record.url?scp=85158018679&partnerID=8YFLogxK
U2 - 10.3390/cryst13040611
DO - 10.3390/cryst13040611
M3 - Article
AN - SCOPUS:85158018679
SN - 2073-4352
VL - 13
JO - Crystals
JF - Crystals
IS - 4
M1 - 611
ER -