TY - JOUR
T1 - Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease
AU - Krebs, Christian F.
AU - Reimers, Daniel
AU - Zhao, Yu
AU - Paust, Hans Joachim
AU - Bartsch, Patricia
AU - Nuñez, Sarah
AU - Rosemblatt, Mariana V.
AU - Hellmig, Malte
AU - Kilian, Christoph
AU - Borchers, Alina
AU - Enk, Leon U.B.
AU - Zinke, Michael
AU - Becker, Martina
AU - Schmid, Joanna
AU - Klinge, Stefanie
AU - Wong, Milagros N.
AU - Puelles, Victor G.
AU - Schmidt, Constantin
AU - Bertram, Tabea
AU - Stumpf, Natascha
AU - Hoxha, Elion
AU - Meyer-Schwesinger, Catherine
AU - Lindenmeyer, Maja T.
AU - Cohen, Clemens D.
AU - Rink, Michael
AU - Kurts, Christian
AU - Franzenburg, Sören
AU - Koch-Nolte, Friedrich
AU - Turner, Jan Eric
AU - Riedel, Jan Hendrik
AU - Huber, Samuel
AU - Gagliani, Nicola
AU - Huber, Tobias B.
AU - Wiech, Thorsten
AU - Rohde, Holger
AU - Bono, Maria Rosa
AU - Bonn, Stefan
AU - Panzer, Ulf
AU - Mittrücker, Hans Willi
N1 - Publisher Copyright:
© 2020 American Association for the Advancement of Science. All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Although it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (TRM) cells persist in peripheral organs and provide immune protection against reinfection. However, whether TRM cells participate in responses unrelated to the primary infection, such as autoimmune inflammation, is unknown. By using high-dimensional single-cell analysis, we identified CD4+ TRM cells with a TH17 signature (termed TRM17 cells) in kidneys of patients with ANCA-associated glomerulonephritis. Experimental models demonstrated that renal TRM17 cells were induced by pathogens infecting the kidney, such as Staphylococcus aureus, Candida albicans, and uropathogenic Escherichia coli, and persisted after the clearance of infections. Upon induction of experimental glomerulonephritis, these kidney TRM17 cells rapidly responded to local proinflammatory cytokines by producing IL-17A and thereby exacerbate renal pathology. Thus, our data show that pathogen-induced TRM17 cells have a previously unrecognized function in aggravating autoimmune disease.
AB - Although it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (TRM) cells persist in peripheral organs and provide immune protection against reinfection. However, whether TRM cells participate in responses unrelated to the primary infection, such as autoimmune inflammation, is unknown. By using high-dimensional single-cell analysis, we identified CD4+ TRM cells with a TH17 signature (termed TRM17 cells) in kidneys of patients with ANCA-associated glomerulonephritis. Experimental models demonstrated that renal TRM17 cells were induced by pathogens infecting the kidney, such as Staphylococcus aureus, Candida albicans, and uropathogenic Escherichia coli, and persisted after the clearance of infections. Upon induction of experimental glomerulonephritis, these kidney TRM17 cells rapidly responded to local proinflammatory cytokines by producing IL-17A and thereby exacerbate renal pathology. Thus, our data show that pathogen-induced TRM17 cells have a previously unrecognized function in aggravating autoimmune disease.
UR - http://www.scopus.com/inward/record.url?scp=85089301829&partnerID=8YFLogxK
U2 - 10.1126/SCIIMMUNOL.ABA4163
DO - 10.1126/SCIIMMUNOL.ABA4163
M3 - Article
C2 - 32769171
AN - SCOPUS:85089301829
SN - 2470-9468
VL - 5
JO - Science Immunology
JF - Science Immunology
IS - 50
M1 - 4163
ER -