Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss

Vicente Medel; Paul H. Delano; Chama Belkhiria; Alexis Leiva; Cristina De Gatica; Victor Vidal; Carlos F. Navarro; Simon San Martín; Melissa Martínez; Christine Gierke; Ximena García; Mauricio Cerda; Rodrigo Vergara; Carolina Delgado; Gonzalo A. Farías

doi:10.1002/dad2.12467

Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss

Vicente Medel, Paul H. Delano, Chama Belkhiria, Alexis Leiva, Cristina De Gatica, Victor Vidal, Carlos F. Navarro, Simon San Martín, Melissa Martínez, Christine Gierke, Ximena García, Mauricio Cerda, Rodrigo Vergara, Carolina Delgado, Gonzalo A. Farías^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

INTRODUCTION: Age-related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss. METHODS: We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age. RESULTS: We found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR-SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB). DISCUSSION: Our findings suggest that DPOAEs may be a non-invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.

Idioma original	Inglés
Número de artículo	e12467
Publicación	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volumen	16
N.º	1
DOI	https://doi.org/10.1002/dad2.12467
Estado	Publicada - 2024

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Publisher Copyright:
© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Áreas temáticas de ASJC Scopus

Neurología clínica
Psiquiatría y salud mental

ODS de las Naciones Unidas

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Medel, V., Delano, P. H., Belkhiria, C., Leiva, A., De Gatica, C., Vidal, V., Navarro, C. F., Martín, S. S., Martínez, M., Gierke, C., García, X., Cerda, M., Vergara, R., Delgado, C., & Farías, G. A. (2024). Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 16(1), Artículo e12467. https://doi.org/10.1002/dad2.12467

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title = "Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss",

abstract = "INTRODUCTION: Age-related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss. METHODS: We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age. RESULTS: We found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR-SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB). DISCUSSION: Our findings suggest that DPOAEs may be a non-invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.",

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author = "Vicente Medel and Delano, {Paul H.} and Chama Belkhiria and Alexis Leiva and {De Gatica}, Cristina and Victor Vidal and Navarro, {Carlos F.} and Mart{\'i}n, {Simon San} and Melissa Mart{\'i}nez and Christine Gierke and Ximena Garc{\'i}a and Mauricio Cerda and Rodrigo Vergara and Carolina Delgado and Far{\'i}as, {Gonzalo A.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2024",

month = jan,

day = "1",

doi = "10.1002/dad2.12467",

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volume = "16",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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Medel, V, Delano, PH, Belkhiria, C, Leiva, A, De Gatica, C, Vidal, V, Navarro, CF, Martín, SS, Martínez, M, Gierke, C, García, X, Cerda, M, Vergara, R, Delgado, C & Farías, GA 2024, 'Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 16, n.º 1, e12467. https://doi.org/10.1002/dad2.12467

TY - JOUR

T1 - Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss

AU - Medel, Vicente

AU - Delano, Paul H.

AU - Belkhiria, Chama

AU - Leiva, Alexis

AU - De Gatica, Cristina

AU - Vidal, Victor

AU - Navarro, Carlos F.

AU - Martín, Simon San

AU - Martínez, Melissa

AU - Gierke, Christine

AU - García, Ximena

AU - Cerda, Mauricio

AU - Vergara, Rodrigo

AU - Delgado, Carolina

AU - Farías, Gonzalo A.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - INTRODUCTION: Age-related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss. METHODS: We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age. RESULTS: We found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR-SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB). DISCUSSION: Our findings suggest that DPOAEs may be a non-invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.

AB - INTRODUCTION: Age-related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss. METHODS: We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age. RESULTS: We found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR-SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB). DISCUSSION: Our findings suggest that DPOAEs may be a non-invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.

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SN - 2352-8729

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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ER -

Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss

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ODS de las Naciones Unidas

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