TY - JOUR
T1 - Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function
AU - Ortiz, Macarena
AU - Sánchez, Francisca
AU - Álvarez, Daniela
AU - Flores, Cristian
AU - Salas-Pérez, Francisca
AU - Valenzuela, Rodrigo
AU - Cantin, Claudette
AU - Leiva, Andrea
AU - Crisosto, Nicolás
AU - Maliqueo, Manuel
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/3
Y1 - 2023/3
N2 - Maternal obesity and the imbalance in linoleic acid (C18:2 n-6, LA) and alpha-linolenic acid (C18:3 n-3, ALA) levels are related with hepatic disturbances in the offspring. However, whether these alterations are present during fetal life is not well understood. Obese and normal weight pregnant women were recruited to determine fatty acids (FAs) consumption, FAs profile (in maternal erythrocytes, placenta and neonatal very low-density lipoproteins VLDL) and biomarkers of fetal liver function, such as gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP) and albumin, in umbilical cord blood. Stearic acid (C18:0, ST) was lower, and total n-3 FAs tended to be lower in umbilical cord VLDLs of obese women compared to controls. Independently of maternal obesity, GGT levels in umbilical cord blood was positively correlated with the LA content and negatively correlated with the ALA content in maternal erythrocytes. We conclude that maternal obesity and its imbalance of LA and ALA are associated with changes in biomarkers of fetal liver function.
AB - Maternal obesity and the imbalance in linoleic acid (C18:2 n-6, LA) and alpha-linolenic acid (C18:3 n-3, ALA) levels are related with hepatic disturbances in the offspring. However, whether these alterations are present during fetal life is not well understood. Obese and normal weight pregnant women were recruited to determine fatty acids (FAs) consumption, FAs profile (in maternal erythrocytes, placenta and neonatal very low-density lipoproteins VLDL) and biomarkers of fetal liver function, such as gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP) and albumin, in umbilical cord blood. Stearic acid (C18:0, ST) was lower, and total n-3 FAs tended to be lower in umbilical cord VLDLs of obese women compared to controls. Independently of maternal obesity, GGT levels in umbilical cord blood was positively correlated with the LA content and negatively correlated with the ALA content in maternal erythrocytes. We conclude that maternal obesity and its imbalance of LA and ALA are associated with changes in biomarkers of fetal liver function.
KW - Alpha-linolenic acid
KW - Gamma-glutamyl transferase
KW - Linoleic acid
KW - Non-alcoholic fatty liver disease
KW - Obesity
KW - Very low-density lipoprotein
UR - http://www.scopus.com/inward/record.url?scp=85147826048&partnerID=8YFLogxK
U2 - 10.1016/j.plefa.2023.102541
DO - 10.1016/j.plefa.2023.102541
M3 - Article
C2 - 36736061
AN - SCOPUS:85147826048
SN - 0952-3278
VL - 190
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
M1 - 102541
ER -
