Resumen
| Idioma original | Español (Chile) |
|---|---|
| Páginas (desde-hasta) | 496-512 |
| Número de páginas | 17 |
| Publicación | Schizophrenia Bulletin |
| Volumen | 50 |
| N.º | 3 |
| DOI | |
| Estado | Publicada - 2024 |
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En: Schizophrenia Bulletin, Vol. 50, N.º 3, 01.05.2024, p. 496-512.
Producción científica: Contribución a una revista › Artículo › revisión exhaustiva
TY - JOUR
T1 - Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
T2 - Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
AU - Wannan, Cassandra M.J.
AU - Nelson, Barnaby
AU - Addington, Jean
AU - Allott, Kelly
AU - Anticevic, Alan
AU - Arango, Celso
AU - Baker, Justin T.
AU - Bearden, Carrie E.
AU - Billah, Tashrif
AU - Bouix, Sylvain
AU - Broome, Matthew R.
AU - Buccilli, Kate
AU - Cadenhead, Kristin S.
AU - Calkins, Monica E.
AU - Cannon, Tyrone D.
AU - Cecci, Guillermo
AU - Chen, Eric Yu Hai
AU - Cho, Kang Ik K.
AU - Choi, Jimmy
AU - Clark, Scott R.
AU - Coleman, Michael J.
AU - Conus, Philippe
AU - Corcoran, Cheryl M.
AU - Cornblatt, Barbara A.
AU - Diaz-Caneja, Covadonga M.
AU - Dwyer, Dominic
AU - Ebdrup, Bjørn H.
AU - Ellman, Lauren M.
AU - Fusar-Poli, Paolo
AU - Galindo, Liliana
AU - Gaspar, Pablo A.
AU - Gerber, Carla
AU - Glenthøj, Louise Birkedal
AU - Glynn, Robert
AU - Harms, Michael P.
AU - Horton, Leslie E.
AU - Kahn, René S.
AU - Kambeitz, Joseph
AU - Kambeitz-Ilankovic, Lana
AU - Kane, John M.
AU - Kapur, Tina
AU - Keshavan, Matcheri S.
AU - Kim, Sung Wan
AU - Koutsouleris, Nikolaos
AU - Kubicki, Marek
AU - Kwon, Jun Soo
AU - Langbein, Kerstin
AU - Lewandowski, Kathryn E.
AU - Light, Gregory A.
AU - Mamah, Daniel
AU - Marcy, Patricia J.
AU - Mathalon, Daniel H.
AU - McGorry, Patrick D.
AU - Mittal, Vijay A.
AU - Nordentoft, Merete
AU - Nunez, Angela
AU - Pasternak, Ofer
AU - Pearlson, Godfrey D.
AU - Perez, Jesus
AU - Perkins, Diana O.
AU - Powers, Albert R.
AU - Roalf, David R.
AU - Sabb, Fred W.
AU - Schiffman, Jason
AU - Shah, Jai L.
AU - Smesny, Stefan
AU - Spark, Jessica
AU - Stone, William S.
AU - Strauss, Gregory P.
AU - Tamayo, Zailyn
AU - Torous, John
AU - Upthegrove, Rachel
AU - Vangel, Mark
AU - Verma, Swapna
AU - Wang, Jijun
AU - Rossum, Inge Winter Van
AU - Wolf, Daniel H.
AU - Wolff, Phillip
AU - Wood, Stephen J.
AU - Yung, Alison R.
AU - Agurto, Carla
AU - Alvarez-Jimenez, Mario
AU - Amminger, Paul
AU - Armando, Marco
AU - Asgari-Targhi, Ameneh
AU - Cahill, John
AU - Carrión, Ricardo E.
AU - Castro, Eduardo
AU - Cetin-Karayumak, Suheyla
AU - Mallar Chakravarty, M.
AU - Cho, Youngsun T.
AU - Cotter, David
AU - D’Alfonso, Simon
AU - Ennis, Michaela
AU - Fadnavis, Shreyas
AU - Fonteneau, Clara
AU - Gao, Caroline
AU - Gupta, Tina
AU - Gur, Raquel E.
AU - Gur, Ruben C.
AU - Hamilton, Holly K.
AU - Hoftman, Gil D.
AU - Jacobs, Grace R.
AU - Jarcho, Johanna
AU - Ji, Jie Lisa
AU - Kohler, Christian G.
AU - Lalousis, Paris Alexandros
AU - Lavoie, Suzie
AU - Lepage, Martin
AU - Liebenthal, Einat
AU - Mervis, Josh
AU - Murty, Vishnu
AU - Nicholas, Spero C.
AU - Ning, Lipeng
AU - Penzel, Nora
AU - Poldrack, Russell
AU - Polosecki, Pablo
AU - Pratt, Danielle N.
AU - Rabin, Rachel
AU - Eichi, Habiballah Rahimi
AU - Rathi, Yogesh
AU - Reichenberg, Avraham
AU - Reinen, Jenna
AU - Rogers, Jack
AU - Ruiz-Yu, Bernalyn
AU - Scott, Isabelle
AU - Seitz-Holland, Johanna
AU - Srihari, Vinod H.
AU - Srivastava, Agrima
AU - Thompson, Andrew
AU - Turetsky, Bruce I.
AU - Walsh, Barbara C.
AU - Whitford, Thomas
AU - Wigman, Johanna T.W.
AU - Yao, Beier
AU - Yuen, Hok Pan
AU - Ahmed, Uzair
AU - Byun, Andrew Jin Soo
AU - Chung, Yoonho
AU - Do, Kim
AU - Hendricks, Larry
AU - Huynh, Kevin
AU - Jeffries, Clark
AU - Lane, Erlend
AU - Langholm, Carsten
AU - Lin, Eric
AU - Mantua, Valentina
AU - Santorelli, Gennarina
AU - Ruparel, Kosha
AU - Zoupou, Eirini
AU - Adasme, Tatiana
AU - Addamo, Lauren
AU - Adery, Laura
AU - Ali, Munaza
AU - Auther, Andrea
AU - Aversa, Samantha
AU - Baek, Seon Hwa
AU - Bates, Kelly
AU - Bathery, Alyssa
AU - Bayer, Johanna M.M.
AU - Beedham, Rebecca
AU - Bilgrami, Zarina
AU - Birch, Sonia
AU - Bonoldi, Ilaria
AU - Borders, Owen
AU - Borgatti, Renato
AU - Brown, Lisa
AU - Bruna, Alejandro
AU - Carrington, Holly
AU - Castillo-Passi, Rolando I.
AU - Chen, Justine
AU - Cheng, Nicholas
AU - Ching, Ann Ee
AU - Clifford, Chloe
AU - Colton, Beau Luke
AU - Contreras, Pamela
AU - Corral, Sebastián
AU - Damiani, Stefano
AU - Done, Monica
AU - Estradé, Andrés
AU - Etuka, Brandon Asika
AU - Formica, Melanie
AU - Furlan, Rachel
AU - Geljic, Mia
AU - Germano, Carmela
AU - Getachew, Ruth
AU - Goncalves, Mathias
AU - Haidar, Anastasia
AU - Hartmann, Jessica
AU - Jo, Anna
AU - John, Omar
AU - Kerins, Sarah
AU - Kerr, Melissa
AU - Kesselring, Irena
AU - Kim, Honey
AU - Kim, Nicholas
AU - Kinney, Kyle
AU - Krcmar, Marija
AU - Kotler, Elana
AU - Lafanechere, Melanie
AU - Lee, Clarice
AU - Llerena, Joshua
AU - Markiewicz, Christopher
AU - Matnejl, Priya
AU - Maturana, Alejandro
AU - Mavambu, Aissata
AU - Mayol-Troncoso, Rocío
AU - McDonnell, Amelia
AU - McGowan, Alessia
AU - McLaughlin, Danielle
AU - McIlhenny, Rebecca
AU - McQueen, Brittany
AU - Mebrahtu, Yohannes
AU - Mensi, Martina
AU - Hui, Christy Lai Ming
AU - Suen, Yi Nam
AU - Wong, Stephanie Ming Yin
AU - Morrell, Neal
AU - Omar, Mariam
AU - Partridge, Alice
AU - Phassouliotis, Christina
AU - Pichiecchio, Anna
AU - Politi, Pierluigi
AU - Porter, Christian
AU - Provenzani, Umberto
AU - Prunier, Nicholas
AU - Raj, Jasmine
AU - Ray, Susan
AU - Rayner, Victoria
AU - Reyes, Manuel
AU - Reynolds, Kate
AU - Rush, Sage
AU - Salinas, Cesar
AU - Shetty, Jashmina
AU - Snowball, Callum
AU - Tod, Sophie
AU - Turra-Fariña, Gabriel
AU - Valle, Daniela
AU - Veale, Simone
AU - Whitson, Sarah
AU - Wickham, Alana
AU - Youn, Sarah
AU - Zamorano, Francisco
AU - Zavaglia, Elissa
AU - Zinberg, Jamie
AU - Woods, Scott W.
AU - Shenton, Martha E.
N1 - Publisher Copyright: © 2024 Oxford University Press. All rights reserved.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.
AB - This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.
KW - clinical high risk
KW - consortium
KW - early detection
KW - prediction
KW - prevention
KW - psychosis
UR - http://www.scopus.com/inward/record.url?scp=85189877128&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbae011
DO - 10.1093/schbul/sbae011
M3 - Artículo
C2 - 38451304
SN - 0586-7614
VL - 50
SP - 496
EP - 512
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 3
ER -