Why glucose transport in the brain matters for PET

L. Felipe Barros*, Omar H. Porras, Carla X. Bittner

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaEstudio breverevisión exhaustiva

57 Citas (Scopus)

Resumen

Neuronal activity is fueled by glucose metabolism, a phenomenon exploited in basic research and clinical diagnosis using fluorodeoxyglucose positron emission tomography (FDG-PET). According to the current view, glucose transport into the brain is not rate-limiting; thus, it cannot exert control over metabolism. This article challenges such a view by showing that basal transport hovers near its maximum, making metabolic activation unable to increase flux on its own. In the light of recent evidence on the identity of the cell type that preferentially breaks down glucose, we suggest that FDG-PET reports the synergistic activation of glucose transport and metabolism in astrocytes, rather than in neurons.

Idioma originalInglés
Páginas (desde-hasta)117-119
Número de páginas3
PublicaciónTrends in Neurosciences
Volumen28
N.º3
DOI
EstadoPublicada - 2005
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Neurociencias General

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