Use of real-time functional magnetic resonance imaging-based neurofeedback to downregulate insular cortex in nicotine-addicted smokers

Mohit Rana*, Sergio Ruiz*, Andrea Sánchez Corzo, Axel Muehleck, Sandra Eck, César Salinas, Francisco Zamorano, Claudio Silva, Massimiliano Rea, Anil Batra, Niels Birbaumer, Ranganatha Sitaram*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

7 Citas (Scopus)

Resumen

It has been more than a decade since the first functional magnetic resonance imaging (fMRI)-based neurofeedback approach was successfully implemented. Since then, various studies have demonstrated that participants can learn to voluntarily control a circumscribed brain region. Consequently, real-time fMRI (rtfMRI) provided a novel opportunity to study modifications of behavior due to manipulation of brain activity. Hence, reports of rtfMRI applications to train self-regulation of brain activity and the concomitant modifications in behavioral and clinical conditions such as neurological and psychiatric disorders [e.g., schizophrenia, obsessive compulsive Disorder (OCD), stroke] have rapidly increased. Neuroimaging studies in addiction research have shown that the anterior cingulate cortex, orbitofrontal cortex, and insular cortex are activated during the presentation of drug-associated cues. Also, activity in both left and right insular cortices have been shown to be highly correlated with drug urges when participants are exposed to craving-eliciting cues. Hence, the bilateral insula is of particular importance in researching drug urges and addiction due to its role in the representation of bodily (interoceptive) states. This study explores the use of rtfMRI neurofeedback for the reduction in blood oxygen-level dependent (BOLD) activity in bilateral insular cortices of nicotine-addicted participants. The study also tests if there are neurofeedback training-associated modifications in the implicit attitudes of participants towards nicotine-craving cues and explicit-craving behavior.

Idioma originalInglés
Número de artículoe59441
PublicaciónJournal of Visualized Experiments
Volumen2020
N.º160
DOI
EstadoPublicada - 2020
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
Copyright © 2020 JoVE Journal of Visualized Experiments.

Áreas temáticas de ASJC Scopus

  • Neurociencias General
  • Ingeniería Química General
  • Bioquímica, Genética y Biología Molecular General
  • Inmunología y Microbiología General

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