Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Pierre Bourdely; Giorgio Anselmi; Kristine Vaivode; Rodrigo Nalio Ramos; Yoann Missolo-Koussou; Sofia Hidalgo; Jimena Tosselo; Nicolas Nuñez; Wilfrid Richer; Anne Vincent-Salomon; Alka Saxena; Kristie Wood; Alvaro Lladser; Eliane Piaggio; Julie Helft; Pierre Guermonprez

doi:10.1016/j.immuni.2020.06.002

Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells

Pierre Bourdely, Giorgio Anselmi, Kristine Vaivode, Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Sofia Hidalgo, Jimena Tosselo, Nicolas Nuñez, Wilfrid Richer, Anne Vincent-Salomon, Alka Saxena, Kristie Wood, Alvaro Lladser, Eliane Piaggio, Julie Helft, Pierre Guermonprez^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

204 Citas (Scopus)

Resumen

Bourdely et al. identify human CD88⁻CD1c⁺CD163⁺ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103⁺CD8⁺ T cells in vitro, and their infiltration correlates with CD8⁺CD69⁺CD103⁺ T_RM accumulation in breast tumors.

Idioma original	Inglés
Páginas (desde-hasta)	335-352.e8
Publicación	Immunity
Volumen	53
N.º	2
DOI	https://doi.org/10.1016/j.immuni.2020.06.002
Estado	Publicada - 2020

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Publisher Copyright:
© 2020 The Author(s)

Áreas temáticas de ASJC Scopus

Inmulogía y alergología
Inmunología
Enfermedades infecciosas

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1016/j.immuni.2020.06.002

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Bourdely, P., Anselmi, G., Vaivode, K., Ramos, R. N., Missolo-Koussou, Y., Hidalgo, S., Tosselo, J., Nuñez, N., Richer, W., Vincent-Salomon, A., Saxena, A., Wood, K., Lladser, A., Piaggio, E., Helft, J., & Guermonprez, P. (2020). Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells. Immunity, 53(2), 335-352.e8. https://doi.org/10.1016/j.immuni.2020.06.002

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title = "Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells",

abstract = "Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro, and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.",

keywords = "DC progenitors, DC3s, T, cDC2s, conventional DCs, inflammatory DCs, monocytes, mononuclear phagocytes",

author = "Pierre Bourdely and Giorgio Anselmi and Kristine Vaivode and Ramos, {Rodrigo Nalio} and Yoann Missolo-Koussou and Sofia Hidalgo and Jimena Tosselo and Nicolas Nu{\~n}ez and Wilfrid Richer and Anne Vincent-Salomon and Alka Saxena and Kristie Wood and Alvaro Lladser and Eliane Piaggio and Julie Helft and Pierre Guermonprez",

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year = "2020",

month = aug,

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doi = "10.1016/j.immuni.2020.06.002",

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Bourdely, P, Anselmi, G, Vaivode, K, Ramos, RN, Missolo-Koussou, Y, Hidalgo, S, Tosselo, J, Nuñez, N, Richer, W, Vincent-Salomon, A, Saxena, A, Wood, K, Lladser, A, Piaggio, E, Helft, J & Guermonprez, P 2020, 'Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells', Immunity, vol. 53, n.º 2, pp. 335-352.e8. https://doi.org/10.1016/j.immuni.2020.06.002

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T1 - Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

AU - Bourdely, Pierre

AU - Anselmi, Giorgio

AU - Vaivode, Kristine

AU - Ramos, Rodrigo Nalio

AU - Missolo-Koussou, Yoann

AU - Hidalgo, Sofia

AU - Tosselo, Jimena

AU - Nuñez, Nicolas

AU - Richer, Wilfrid

AU - Vincent-Salomon, Anne

AU - Saxena, Alka

AU - Wood, Kristie

AU - Lladser, Alvaro

AU - Piaggio, Eliane

AU - Helft, Julie

AU - Guermonprez, Pierre

PY - 2020/8/18

Y1 - 2020/8/18

N2 - Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro, and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.

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KW - DC progenitors

KW - DC3s

KW - T

KW - cDC2s

KW - conventional DCs

KW - inflammatory DCs

KW - monocytes

KW - mononuclear phagocytes

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AN - SCOPUS:85087942391

SN - 1074-7613

VL - 53

SP - 335-352.e8

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JF - Immunity

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