The astrocyte: Powerhouse and recycling center

Bruno Weber*, L. Felipe Barros

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

138 Citas (Scopus)

Resumen

Brain metabolism is characterized by fuel monodependence, high-energy expenditure, autonomy from the rest of body, local recycling, and marked division of labor between cell types. Although neurons spend most of the brain’s energy on signaling, astrocytes bear the brunt of the metabolic load, controlling the composition of the interstitial fluid, supplying neurons with energy substrates and precursors for biosynthesis, and recycling neurotransmitters, oxidized scavengers, and other waste products. Outstanding questions in this field are the role of oligodendrocytes, the metabolic behavior of the different subtypes of astrocytes during development and disease, and the emerging notion that metabolism may participate directly in information processing.

Idioma originalInglés
Número de artículoa020396
PublicaciónCold Spring Harbor Perspectives in Biology
Volumen7
N.º12
DOI
EstadoPublicada - 2015
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

Áreas temáticas de ASJC Scopus

  • Bioquímica, Genética y Biología Molecular General

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