@article{1c45490f11e34f9e98437076eea4784b,
title = "Tellurite reduction by Escherichia coli NDH-II dehydrogenase results in superoxide production in membranes of toxicant-exposed cells",
abstract = "Tellurite, the most soluble tellurium oxyanion, is extremely harmful for most microorganisms. Part of this toxicity is due to the generation of reactive oxygen species that in turn cause oxidative stress. However, the way in which tellurite interferes with cellular processes is not well understood to date. Looking for new cellular tellurite targets, we decided to evaluate the functioning of the electron transport chain in tellurite-exposed cells. In this communication we show that the E. coli ndh gene, encoding NDH-II dehydrogenase, is significantly induced in toxicant-exposed cells and that the enzyme displays tellurite-reducing activity that results in increased superoxide levels in vitro.",
keywords = "Electron transport chain, Escherichia coli, NDH-II, Superoxide, Tellurite, Tellurite reductase",
author = "D{\'i}az-V{\'a}squez, {Waldo A.} and Abarca-Lagunas, {Mar{\'i}a J.} and Arenas, {Felipe A.} and Pinto, {Camilo A.} and Cornejo, {Fabi{\'a}n A.} and Wansapura, {Poorna T.} and Appuhamillage, {Gayan A.} and Chasteen, {Thomas G.} and V{\'a}squez, {Claudio C.}",
note = "Funding Information: Acknowledgments The authors thank Dr. J.A. Imlay for providing some of the microorganisms detailed in Table 1. This work received financial support from FONDECYT (Fondo Nacional de Ciencia y Tecnolog{\'i}a) 1090097 and DICYT (Direcci{\'o}n de Investigaci{\'o}n en Ciencia y Tecnolog{\'i}a, Universidad de Santiago de Chile) (CCV). A doctoral fellowship and Grant No. 24121087 from CONICYT (Comisi{\'o}n Nacional de Ciencia y Tecnolog{\'i}a) to WAD-V is also acknowledged. Support from the Robert A. Welch Foundation (X-011) is also gratefully acknowledged for the work at Sam Houston State University.",
year = "2014",
month = apr,
doi = "10.1007/s10534-013-9701-8",
language = "English",
volume = "27",
pages = "237--246",
journal = "BioMetals",
issn = "0966-0844",
publisher = "Springer Netherlands",
number = "2",
}