Tellurite reduction by Escherichia coli NDH-II dehydrogenase results in superoxide production in membranes of toxicant-exposed cells

Waldo A. Díaz-Vásquez, María J. Abarca-Lagunas, Felipe A. Arenas, Camilo A. Pinto, Fabián A. Cornejo, Poorna T. Wansapura, Gayan A. Appuhamillage, Thomas G. Chasteen, Claudio C. Vásquez*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

23 Citas (Scopus)

Resumen

Tellurite, the most soluble tellurium oxyanion, is extremely harmful for most microorganisms. Part of this toxicity is due to the generation of reactive oxygen species that in turn cause oxidative stress. However, the way in which tellurite interferes with cellular processes is not well understood to date. Looking for new cellular tellurite targets, we decided to evaluate the functioning of the electron transport chain in tellurite-exposed cells. In this communication we show that the E. coli ndh gene, encoding NDH-II dehydrogenase, is significantly induced in toxicant-exposed cells and that the enzyme displays tellurite-reducing activity that results in increased superoxide levels in vitro.

Idioma originalInglés
Páginas (desde-hasta)237-246
Número de páginas10
PublicaciónBioMetals
Volumen27
N.º2
DOI
EstadoPublicada - 2014

Áreas temáticas de ASJC Scopus

  • Biomateriales
  • Bioquímica, Genética y Biología Molecular General
  • Ciencias Agrícolas y Biológicas General
  • Metales y aleaciones

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