@inbook{bc57575bb3d3425097d0c8dea187c1cb,
title = "T-cell homing to the gut mucosa: General concepts and methodological considerations",
abstract = "Effector/memory T cells can migrate to most extra-lymphoid tissues in the body. However, migration to the intestinal mucosa requires the expression of very specific homing receptors on T cells, integrin α4β7 and chemokine receptor CCR9. These receptors are induced by all-trans retinoic acid (RA), a vitamin A metabolite that is specifically synthesized by gut-associated dendritic cells (DC), but not by extra-intestinal DC. Here we summarize some general concepts on T cell homing with an emphasis on the gut mucosa. We also discuss experimental strategies to generate gut-homing T cells in vivo and in vitro and the techniques to track gut-homing T cells.",
keywords = "CCL25, CCR9, Chemotaxis, DC, GALT, Gut homing, Homing, RALDH, Retinoic acid, Small intestine, α4β7",
author = "{De Calisto}, Jaime and Villablanca, {Eduardo J.} and Sen Wang and Bono, {Maria R.} and Mario Rosemblatt and Mora, {J. Rodrigo}",
year = "2011",
doi = "10.1007/978-1-61779-166-6_24",
language = "English",
isbn = "9781617791659",
series = "Methods in Molecular Biology",
pages = "411--434",
editor = "Motomu Shimaoka and Motomu Shimaoka",
booktitle = "Integrin and Cell Adhesion Molecules",
}