Slight ph fluctuations in the gold nanoparticle synthesis process influence the performance of the citrate reduction method

Braulio Contreras-Trigo, Víctor Díaz-García, Enrique Guzmán-Gutierrez, Ignacio Sanhueza, Pablo Coelho, Sebastián E. Godoy, Sergio Torres, Patricio Oyarzún*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

39 Citas (Scopus)

Resumen

Gold nanoparticles (AuNPs) are currently under intense investigation for biomedical and biotechnology applications, thanks to their ease in preparation, stability, biocompatibility, multiple surface functionalities, and size-dependent optical properties. The most commonly used method for AuNP synthesis in aqueous solution is the reduction of tetrachloroauric acid (HAuCl4) with trisodium citrate. We have observed variations in the pH and in the concentration of the gold colloidal suspension synthesized under standard conditions, verifying a reduction in the reaction yield by around 46% from pH 5.3 (2.4 nM) to pH 4.7 (1.29 nM). Citrate-capped AuNPs were characterized by UV-visible spectroscopy, TEM, EDS, and zeta-potential measurements, revealing a linear correlation between pH and the concentration of the generated AuNPs. This result can be attributed to the adverse effect of protons both on citrate oxidation and on citrate adsorption onto the gold surface, which is required to form the stabilization layer. Overall, this study provides insight into the effect of the pH over the synthesis performance of the method, which would be of particular interest from the point of view of large-scale manufacturing processes.

Idioma originalInglés
Número de artículo2246
PublicaciónSensors (Switzerland)
Volumen18
N.º7
DOI
EstadoPublicada - 2018

Nota bibliográfica

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Áreas temáticas de ASJC Scopus

  • Química analítica
  • Instrumental
  • Óptica y física atómica y molecular
  • Ingeniería eléctrica y electrónica
  • Bioquímica

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