Resumen
Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 6-13 |
Número de páginas | 8 |
Publicación | Journal of Neuroimmunology |
Volumen | 251 |
N.º | 1-2 |
DOI | |
Estado | Publicada - 2012 |
Publicado de forma externa | Sí |
Áreas temáticas de ASJC Scopus
- Inmulogía y alergología
- Inmunología
- Neurología
- Neurología clínica