RUNX family: Oncogenes or tumor suppressors (Review)

Beatriz Andrea Otálora-Otálora, Berta Henríquez, Liliana López-Kleine, Adriana Rojas*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

61 Citas (Scopus)

Resumen

Runt-related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.

Idioma originalInglés
Páginas (desde-hasta)3-19
Número de páginas17
PublicaciónOncology Reports
Volumen42
N.º1
DOI
EstadoPublicada - 2019

Nota bibliográfica

Publisher Copyright:
© 2019 Spandidos Publications. All rights reserved.

Áreas temáticas de ASJC Scopus

  • Oncología
  • Investigación sobre el cáncer

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