Role of voltage-gated proton channel (Hv1) in cancer biology

Juan J. Alvear-Arias, Antonio Pena-Pichicoi, Christian Carrillo, Miguel Fernandez, Tania Gonzalez, Jose A. Garate, Carlos Gonzalez*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

2 Citas (Scopus)

Resumen

The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by changes in the patterns of expression of certain proton transporters. In the past decade, the voltage-gated proton channel (Hv1) has been added to this list and is increasingly being recognized as a target with onco-therapeutic potential. The Hv1 channel is key to proton extrusion for maintaining a balanced cytosolic pH. This protein-channel is expressed in a myriad of tissues and cell lineages whose functions vary from producing bioluminescence in dinoflagellates to alkalizing spermatozoa cytoplasm for reproduction, and regulating the respiratory burst for immune system response. It is no wonder that in acidic environments such as the tumor microenvironment, an exacerbated expression and function of this channel has been reported. Indeed, multiple studies have revealed a strong relationship between pH balance, cancer development, and the overexpression of the Hv1 channel, being proposed as a marker for malignancy in cancer. In this review, we present data that supports the idea that the Hv1 channel plays a significant role in cancer by maintaining pH conditions that favor the development of malignancy features in solid tumor models. With the antecedents presented in this bibliographic report, we want to strengthen the idea that the Hv1 proton channel is an excellent therapeutic strategy to counter the development of solid tumors.

Idioma originalInglés
Número de artículo1175702
PublicaciónFrontiers in Pharmacology
Volumen14
DOI
EstadoPublicada - 2023

Nota bibliográfica

Funding Information:
This work was supported by Agencia Naional de Investigación y Desarrollo (ANID) /Programa Formación de Capital Humano Avanzado/Doctorado Nacional/2019-21200727 to JA-A, 2019-21200754 to CC, 2019-21191239 to AP-P, 2017-21171141 to MF, Fondecyt grant 1221260 to JG. The Nucleus in NanoBiophysics (NNBP) is funded by the ANID-Millenium Science Initiative Program Project NCN2021_021. Centro Ciencia y Vida is funded by Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia de ANID FB210008, (JG).

Publisher Copyright:
Copyright © 2023 Alvear-Arias, Pena-Pichicoi, Carrillo, Fernandez, Gonzalez, Garate and Gonzalez.

Áreas temáticas de ASJC Scopus

  • Farmacología
  • Farmacología (médica)

Huella

Profundice en los temas de investigación de 'Role of voltage-gated proton channel (Hv1) in cancer biology'. En conjunto forman una huella única.

Citar esto