TY - JOUR
T1 - Retinoic acid generates regulatory T cells in experimental transplantation
AU - Moore, C.
AU - Fuentes, C.
AU - Sauma, D.
AU - Morales, J.
AU - Bono, M. R.
AU - Rosemblatt, M.
AU - Fierro, J. A.
N1 - Funding Information:
Supported by Fondecyt 1100557, 1100448, 1080416.
PY - 2011/7
Y1 - 2011/7
N2 - Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β and interleukin (IL) 2, generated allogeneic regulatory T cells de novo. These cells were able to inhibit skin rejection in adoptive transfer experiments. The generation of regulatory T cells ex vivo with retinoic acid, TGF-β, and IL-2 represents a new step toward specific regulation of allogeneic immune responses.
AB - Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory T cells. Naive T cells, coincubated with allogeneic antigen-presenting cells and retinoic acid, in conjunction with transforming growth factor (TGF) β and interleukin (IL) 2, generated allogeneic regulatory T cells de novo. These cells were able to inhibit skin rejection in adoptive transfer experiments. The generation of regulatory T cells ex vivo with retinoic acid, TGF-β, and IL-2 represents a new step toward specific regulation of allogeneic immune responses.
UR - http://www.scopus.com/inward/record.url?scp=80051704283&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2011.06.057
DO - 10.1016/j.transproceed.2011.06.057
M3 - Article
C2 - 21839265
AN - SCOPUS:80051704283
SN - 0041-1345
VL - 43
SP - 2334
EP - 2337
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 6
ER -