TY - JOUR
T1 - Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain
AU - Faure-André, Gabrielle
AU - Vargas, Pablo
AU - Yuseff, Maria Isabel
AU - Heuzé, Mélina
AU - Diaz, Jheimmy
AU - Lankar, Danielle
AU - Steri, Veronica
AU - Manry, Jeremy
AU - Hugues, Stéphanie
AU - Vascotto, Fulvia
AU - Boulanger, Jérôme
AU - Raposo, Graça
AU - Bono, Maria Rosa
AU - Rosemblatt, Mario
AU - Piel, Matthieu
AU - Lennon-Duménil, Ana Maria
PY - 2008/12/12
Y1 - 2008/12/12
N2 - Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.
AB - Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.
UR - http://www.scopus.com/inward/record.url?scp=58149247727&partnerID=8YFLogxK
U2 - 10.1126/science.1159894
DO - 10.1126/science.1159894
M3 - Article
C2 - 19074353
AN - SCOPUS:58149247727
SN - 0036-8075
VL - 322
SP - 1705
EP - 1710
JO - Science
JF - Science
IS - 5908
ER -