Preeclampsia, placenta, oxidative stress, and PMCA

Cilia Abad; Teresa Proverbio; Sandy Piñero; Desirée Botana; Delia I. Chiarello; Reinaldo Marín; Fulgencio Proverbio

doi:10.3109/10641955.2012.690058

Preeclampsia, placenta, oxidative stress, and PMCA

Cilia Abad, Teresa Proverbio, Sandy Piñero, Desirée Botana, Delia I. Chiarello, Reinaldo Marín, Fulgencio Proverbio^*

^*Autor correspondiente de este trabajo

Instituto Venezolano de Investigaciones Científicas

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

24 Citas (Scopus)

Resumen

Objective: The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration. Methods: Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included. Results: Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described. Conclusions: Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.

Idioma original	Inglés
Páginas (desde-hasta)	427-441
Número de páginas	15
Publicación	Hypertension in Pregnancy
Volumen	31
N.º	4
DOI	https://doi.org/10.3109/10641955.2012.690058
Estado	Publicada - 2012
Publicado de forma externa	Sí

Áreas temáticas de ASJC Scopus

Medicina interna
Ginecología y obstetricia

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10.3109/10641955.2012.690058

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title = "Preeclampsia, placenta, oxidative stress, and PMCA",

abstract = "Objective: The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration. Methods: Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included. Results: Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described. Conclusions: Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.",

keywords = "Calcium, Oxidative stress, PMCA, Placenta, Preeclampsia",

author = "Cilia Abad and Teresa Proverbio and Sandy Pi{\~n}ero and Desir{\'e}e Botana and Chiarello, {Delia I.} and Reinaldo Mar{\'i}n and Fulgencio Proverbio",

note = "Funding Information: This study was supported in part by grant no. H9/181/R427, project 96350, from the World Health Organization and by grant from FONACIT-Venezuela no. F-2005000222.",

year = "2012",

month = nov,

doi = "10.3109/10641955.2012.690058",

language = "English",

volume = "31",

pages = "427--441",

journal = "Hypertension in Pregnancy",

issn = "1064-1955",

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TY - JOUR

T1 - Preeclampsia, placenta, oxidative stress, and PMCA

AU - Abad, Cilia

AU - Proverbio, Teresa

AU - Piñero, Sandy

AU - Botana, Desirée

AU - Chiarello, Delia I.

AU - Marín, Reinaldo

AU - Proverbio, Fulgencio

N1 - Funding Information: This study was supported in part by grant no. H9/181/R427, project 96350, from the World Health Organization and by grant from FONACIT-Venezuela no. F-2005000222.

PY - 2012/11

Y1 - 2012/11

N2 - Objective: The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration. Methods: Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included. Results: Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described. Conclusions: Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.

AB - Objective: The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration. Methods: Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included. Results: Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described. Conclusions: Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.

KW - Calcium

KW - Oxidative stress

KW - PMCA

KW - Placenta

KW - Preeclampsia

UR - http://www.scopus.com/inward/record.url?scp=84867062945&partnerID=8YFLogxK

U2 - 10.3109/10641955.2012.690058

DO - 10.3109/10641955.2012.690058

M3 - Review article

C2 - 22676487

AN - SCOPUS:84867062945

SN - 1064-1955

VL - 31

SP - 427

EP - 441

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

IS - 4

ER -

Preeclampsia, placenta, oxidative stress, and PMCA

Resumen

Áreas temáticas de ASJC Scopus

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