TY - JOUR
T1 - Photobiomodulation Therapy in Burn Wound Healing
T2 - Systematic Review and Meta-Analysis of Preclinical Studies
AU - Deana, Naira Figueiredo
AU - Alves, Nilton
AU - Zaror, Carlos
AU - Del Sol, Mariano
AU - Bagnato, Vanderlei Salvador
N1 - Publisher Copyright:
© 2021, Mary Ann Liebert, Inc., publishers.
PY - 2021/7
Y1 - 2021/7
N2 - Background and objective: To determine the effectiveness of photobiomodulation therapy (PBMT) in the burn wound healing compared with the control or with the use of antibiotics, in animal models. Materials and methods: A systematic search was conducted in EMBASE, MEDLINE, and LILACS databases. Preclinical studies were included that analyzed the effectiveness of PBMT in the burn wound healing, which assessed wound contraction, angiogenesis, proliferation of fibroblasts, and collagen deposition. SYRCLE risk of bias tool was used. Random effects models were used to estimate the pooled effect. Results: Thirty-eight studies were included. PBMT favored wound contraction (mean difference =-11.47, 95% confidence interval-19.87 to-3.08, I2 = 0%; moderate certainty of evidence). PBMT also favored angiogenesis at doses between 11 and 20 J/cm2, and increased the collagenization rate. Conclusions: In animal models, PBMT favored wound contraction, angiogenesis, and collagen deposition in second-and third-degree burn wounds.
AB - Background and objective: To determine the effectiveness of photobiomodulation therapy (PBMT) in the burn wound healing compared with the control or with the use of antibiotics, in animal models. Materials and methods: A systematic search was conducted in EMBASE, MEDLINE, and LILACS databases. Preclinical studies were included that analyzed the effectiveness of PBMT in the burn wound healing, which assessed wound contraction, angiogenesis, proliferation of fibroblasts, and collagen deposition. SYRCLE risk of bias tool was used. Random effects models were used to estimate the pooled effect. Results: Thirty-eight studies were included. PBMT favored wound contraction (mean difference =-11.47, 95% confidence interval-19.87 to-3.08, I2 = 0%; moderate certainty of evidence). PBMT also favored angiogenesis at doses between 11 and 20 J/cm2, and increased the collagenization rate. Conclusions: In animal models, PBMT favored wound contraction, angiogenesis, and collagen deposition in second-and third-degree burn wounds.
KW - burn
KW - photobiomodulation therapy
KW - preclinical study
KW - wound contraction
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85110722807&partnerID=8YFLogxK
U2 - 10.1089/photob.2020.4972
DO - 10.1089/photob.2020.4972
M3 - Review article
C2 - 34264767
AN - SCOPUS:85110722807
SN - 2578-5478
VL - 39
SP - 439
EP - 452
JO - Photobiomodulation, Photomedicine, and Laser Surgery
JF - Photobiomodulation, Photomedicine, and Laser Surgery
IS - 7
ER -