Patient values and preferences regarding VTE disease: A systematic review to inform American Society of Hematology guidelines

Itziar Etxeandia-Ikobaltzeta*, Yuan Zhang, Francesca Brundisini, Ivan D. Florez, Wojtek Wiercioch, Robby Nieuwlaat, Housne Begum, Carlos A. Cuello, Yetiani Roldan, Ru Chen, Chengyi Ding, Rebecca L. Morgan, John J. Riva, Yuqing Zhang, Rana Charide, Arnav Agarwal, Sara Balduzzi, Gian Paolo Morgano, Juan Jose Yepes-Nuñez, Yasir RehmanIgnacio Neumann, Nicole Schwab, Tejan Baldeh, Cody Braun, Maria Francisca Rodriguez, Holger J. Schunemann

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

34 Citas (Scopus)

Resumen

Values and preferences relate to the importance that patients place on health outcomes (eg, bleeding, having a deep venous thrombosis) and are essential when weighing benefits and harms in guideline recommendations. To inform the American Society of Hematology guidelines for management of venous thromboembolism (VTE) disease, we conducted a systematic review of patients' values and preferences related to VTE. We searched Medline, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature from inception to April of 2018 (PROSPEROCRD42018094003). We included quantitative and qualitative studies.We followed Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance for rating the certainty and presenting findings for quantitative research about the relative importance of health outcomes and a grounded theory approach for qualitative thematic synthesis. We identified 14 quantitative studies (2465 participants) describing the relative importance of VTE-related health states in a widely diverse population of patients, showing overall small to important impact on patients' lives (certainty of the evidence from low to moderate). Additionally, evidence from 34 quantitative studies (6424 participants) and 15 qualitative studies (570 participants) revealed that patients put higher value on VTE risk reduction than on the potential harms of the treatment (certainty of evidence from low to moderate). Studies also suggested a clear preference for oral medication over subcutaneous medication (moderate certainty). The observed variability in health state values may be a result of differences in the approaches used to elicit them and the diversity of included populations rather than true variability in values. This finding highlights the necessity to explore the variability induced by different approaches to ascertain values.

Idioma originalInglés
Páginas (desde-hasta)953-968
Número de páginas16
PublicaciónBlood Advances
Volumen4
N.º5
DOI
EstadoPublicada - 2020

Nota bibliográfica

Publisher Copyright:
© 2020 by The American Society of Hematology.

Áreas temáticas de ASJC Scopus

  • Hematología

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