Necrotic volume increase and the early physiology of necrosis

L. F. Barros*, T. Hermosilla, J. Castro

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

131 Citas (Scopus)

Resumen

Whether a lethally injured mammalian cell undergoes necrosis or apoptosis may be determined by the early activation of specific ion channels at the cell surface. Apoptosis requires K+ and Cl- efflux, which leads to cell shrinking, an active phenomenon termed apoptotic volume decrease (AVD). In contrast, necrosis has been shown to require Na+ influx through membrane carriers and more recently through stress-activated non-selective cation channels (NSCCs). These ubiquitous channels are kept dormant in viable cells but become activated upon exposure to free-radicals. The ensuing Na+ influx leads to cell swelling, an active response that may be termed necrotic volume increase (NVI). This review focuses on how AVD and NVI become conflicting forces at the beginning of cell injury, on the events that determine irreversibility and in particular, on the ion fluxes that decide whether a cell is to die by necrosis or by apoptosis.

Idioma originalInglés
Páginas (desde-hasta)401-409
Número de páginas9
PublicaciónComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Volumen130
N.º3
DOI
EstadoPublicada - 2001
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Biología molecular
  • Bioquímica
  • Fisiología

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