Metabolic signaling by lactate in the brain

L. Felipe Barros*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

261 Citas (Scopus)

Resumen

High-resolution molecular and imaging techniques are shedding light on the mechanisms and functional significance of the transient rise in tissue lactate that accompanies synaptic activity. Despite high energy needs, neurons have a truncated glycolytic pathway that favors antioxidation over energy production, whereas astrocytes team up with oligodendrocytes to extract glucose from the blood, mobilize glycogen, and release lactate under neuronal command. Lactate energizes neurons but also diffuses beyond the active zone and modifies the activity of neurons and astrocytes in neighboring regions. Involved in a hierarchy of processes from neurovascular coupling to memory formation, lactate has a dual role as metabolic fuel and an intercellular messenger.

Idioma originalInglés
Páginas (desde-hasta)396-404
Número de páginas9
PublicaciónTrends in Neurosciences
Volumen36
N.º7
DOI
EstadoPublicada - 2013
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Neurociencias General

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