TY - JOUR
T1 - KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
AU - Tapia, Diego
AU - Jiménez, Tomás
AU - Zamora, Constanza
AU - Espinoza, Javier
AU - Rizzo, Riccardo
AU - González-Cárdenas, Alexis
AU - Fuentes, Danitza
AU - Hernández, Sergio
AU - Cavieres, Viviana A.
AU - Soza, Andrea
AU - Guzmán, Fanny
AU - Arriagada, Gloria
AU - Yuseff, María Isabel
AU - Mardones, Gonzalo A.
AU - Burgos, Patricia V.
AU - Luini, Alberto
AU - González, Alfonso
AU - Cancino, Jorge
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named ‘traffic-induced degradation response for secretion’ (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.
AB - Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named ‘traffic-induced degradation response for secretion’ (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.
UR - http://www.scopus.com/inward/record.url?scp=85061484658&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-08501-w
DO - 10.1038/s41467-019-08501-w
M3 - Article
C2 - 30760704
AN - SCOPUS:85061484658
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 735
ER -