Ion movements in cell death: From protection to execution

Luis Felipe Barros*, Joel Castro, Carla X. Bittner

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

40 Citas (Scopus)

Resumen

Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+l and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+] and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers.

Idioma originalInglés
Páginas (desde-hasta)209-214
Número de páginas6
PublicaciónBiological Research
Volumen35
N.º2
EstadoPublicada - 2002
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Bioquímica, Genética y Biología Molecular General
  • Ciencias Agrícolas y Biológicas General

Huella

Profundice en los temas de investigación de 'Ion movements in cell death: From protection to execution'. En conjunto forman una huella única.

Citar esto