TY - JOUR
T1 - Intratask variability as a correlate for DRD4 and SLC6A3 variants
T2 - A pilot study in ADHD
AU - Henríquez-Henríquez, Marcela
AU - Villarroel, Luis
AU - Henríquez, Hugo
AU - Zamorano, Francisco
AU - Rothhammer, Francisco
AU - Aboitiz, Francisco
N1 - Publisher Copyright:
© The Author(s) 2012.
PY - 2015/11
Y1 - 2015/11
N2 - Behavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixedeffect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p =.046) and cumulative increments in the correct responses to “NoGo” (p =.00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to “Go” (p =.0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/ inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.
AB - Behavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixedeffect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p =.046) and cumulative increments in the correct responses to “NoGo” (p =.00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to “Go” (p =.0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/ inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.
KW - ADHD
KW - Genetic variants
KW - Within-subject variability
UR - http://www.scopus.com/inward/record.url?scp=84943549479&partnerID=8YFLogxK
U2 - 10.1177/1087054712455844
DO - 10.1177/1087054712455844
M3 - Article
C2 - 22930791
AN - SCOPUS:84943549479
SN - 1087-0547
VL - 19
SP - 987
EP - 996
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 11
ER -