Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8+ T-cells favoring anti-tumor immunity

Claudio Figueroa; Felipe Gálvez-Cancino; Cesar Oyarce; Francisco Contreras; Carolina Prado; Catalina Valeria; Sebastián Cruz; Alvaro Lladser; Rodrigo Pacheco

doi:10.1016/j.jneuroim.2016.12.014

Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8⁺ T-cells favoring anti-tumor immunity

Claudio Figueroa, Felipe Gálvez-Cancino, Cesar Oyarce, Francisco Contreras, Carolina Prado, Catalina Valeria, Sebastián Cruz, Alvaro Lladser, Rodrigo Pacheco^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

26 Citas (Scopus)

Resumen

Dendritic cells (DCs) display the unique ability for cross-presenting antigens to CD8⁺ T-cells, promoting their differentiation into cytotoxic T-lymphocytes (CTLs), which play a pivotal role in anti-tumor immunity. Emerging evidence points to dopamine receptor D3 (D3R) as a key regulator of immunity. Accordingly, we studied how D3R regulates DCs function in anti-tumor immunity. The results show that D3R-deficiency in DCs enhanced expansion of CTLs in vivo and induced stronger anti-tumor immunity. Co-culture experiments indicated that D3R-inhibition in DCs potentiated antigen cross-presentation and CTLs activation. Our findings suggest that D3R in DCs constitutes a new therapeutic target to strengthen anti-tumor immunity.

Idioma original	Inglés
Páginas (desde-hasta)	99-107
Número de páginas	9
Publicación	Journal of Neuroimmunology
Volumen	303
DOI	https://doi.org/10.1016/j.jneuroim.2016.12.014
Estado	Publicada - 2017

Nota bibliográfica

Publisher Copyright:
© 2016 Elsevier B.V.

Áreas temáticas de ASJC Scopus

Inmulogía y alergología
Inmunología
Neurología
Neurología clínica

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10.1016/j.jneuroim.2016.12.014

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title = "Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8+ T-cells favoring anti-tumor immunity",

abstract = "Dendritic cells (DCs) display the unique ability for cross-presenting antigens to CD8+ T-cells, promoting their differentiation into cytotoxic T-lymphocytes (CTLs), which play a pivotal role in anti-tumor immunity. Emerging evidence points to dopamine receptor D3 (D3R) as a key regulator of immunity. Accordingly, we studied how D3R regulates DCs function in anti-tumor immunity. The results show that D3R-deficiency in DCs enhanced expansion of CTLs in vivo and induced stronger anti-tumor immunity. Co-culture experiments indicated that D3R-inhibition in DCs potentiated antigen cross-presentation and CTLs activation. Our findings suggest that D3R in DCs constitutes a new therapeutic target to strengthen anti-tumor immunity.",

keywords = "Antigen cross-presentation, Cytotoxic T lymphocytes, Dendritic cells, Dopamine receptors, Knockout mice, Tumor immunology",

author = "Claudio Figueroa and Felipe G{\'a}lvez-Cancino and Cesar Oyarce and Francisco Contreras and Carolina Prado and Catalina Valeria and Sebasti{\'a}n Cruz and Alvaro Lladser and Rodrigo Pacheco",

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doi = "10.1016/j.jneuroim.2016.12.014",

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T1 - Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8+ T-cells favoring anti-tumor immunity

AU - Figueroa, Claudio

AU - Gálvez-Cancino, Felipe

AU - Oyarce, Cesar

AU - Contreras, Francisco

AU - Prado, Carolina

AU - Valeria, Catalina

AU - Cruz, Sebastián

AU - Lladser, Alvaro

AU - Pacheco, Rodrigo

PY - 2017/2/15

Y1 - 2017/2/15

N2 - Dendritic cells (DCs) display the unique ability for cross-presenting antigens to CD8+ T-cells, promoting their differentiation into cytotoxic T-lymphocytes (CTLs), which play a pivotal role in anti-tumor immunity. Emerging evidence points to dopamine receptor D3 (D3R) as a key regulator of immunity. Accordingly, we studied how D3R regulates DCs function in anti-tumor immunity. The results show that D3R-deficiency in DCs enhanced expansion of CTLs in vivo and induced stronger anti-tumor immunity. Co-culture experiments indicated that D3R-inhibition in DCs potentiated antigen cross-presentation and CTLs activation. Our findings suggest that D3R in DCs constitutes a new therapeutic target to strengthen anti-tumor immunity.

AB - Dendritic cells (DCs) display the unique ability for cross-presenting antigens to CD8+ T-cells, promoting their differentiation into cytotoxic T-lymphocytes (CTLs), which play a pivotal role in anti-tumor immunity. Emerging evidence points to dopamine receptor D3 (D3R) as a key regulator of immunity. Accordingly, we studied how D3R regulates DCs function in anti-tumor immunity. The results show that D3R-deficiency in DCs enhanced expansion of CTLs in vivo and induced stronger anti-tumor immunity. Co-culture experiments indicated that D3R-inhibition in DCs potentiated antigen cross-presentation and CTLs activation. Our findings suggest that D3R in DCs constitutes a new therapeutic target to strengthen anti-tumor immunity.

KW - Antigen cross-presentation

KW - Cytotoxic T lymphocytes

KW - Dendritic cells

KW - Dopamine receptors

KW - Knockout mice

KW - Tumor immunology

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JF - Journal of Neuroimmunology

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