TY - JOUR
T1 - Influence of titanium dioxide nanoparticles on 2,3,7,8-tetrachlorodibenzo-p-dioxin bioconcentration and toxicity in the marine fish European sea bass (Dicentrarchus labrax)
AU - Della Torre, Camilla
AU - Buonocore, Francesco
AU - Frenzilli, Giada
AU - Corsolini, Simonetta
AU - Brunelli, Andrea
AU - Guidi, Patrizia
AU - Kocan, Anton
AU - Mariottini, Michela
AU - Mottola, Filomena
AU - Nigro, Marco
AU - Pozo, Karla
AU - Randelli, Elisa
AU - Vannuccini, Maria Luisa
AU - Picchietti, Simona
AU - Santonastaso, Marianna
AU - Scarcelli, Vittoria
AU - Focardi, Silvano
AU - Marcomini, Antonio
AU - Rocco, Lucia
AU - Scapigliati, Giuseppe
AU - Corsi, Ilaria
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/1
Y1 - 2015/1
N2 - The present study investigated the influence of nano-TiO2 (1 mg L-1) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg L-1) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano-TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.
AB - The present study investigated the influence of nano-TiO2 (1 mg L-1) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg L-1) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano-TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.
KW - 2,3,7,8-TCDD
KW - CYP1A
KW - Genotoxicity
KW - Immunomodulation
KW - Nano-TiO
UR - http://www.scopus.com/inward/record.url?scp=84916901143&partnerID=8YFLogxK
U2 - 10.1016/j.envpol.2014.09.020
DO - 10.1016/j.envpol.2014.09.020
M3 - Article
C2 - 25463713
AN - SCOPUS:84916901143
SN - 0269-7491
VL - 196
SP - 185
EP - 193
JO - Environmental Pollution
JF - Environmental Pollution
M1 - 7682
ER -
