TY - JOUR
T1 - Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application
AU - Jayaramudu, Tippabattini
AU - Varaprasad, Kokkarachedu
AU - Pyarasani, Radha D.
AU - Reddy, K. Koteshwara
AU - Akbari-Fakhrabadi, A.
AU - Carrasco-Sánchez, Verónica
AU - Amalraj, John
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/2/15
Y1 - 2021/2/15
N2 - Currently, special emphasis is being given to the design and fabrication of antibacterial nanocomposite hydrogels for wound dressing applications. Herein, we report the synthesis and characterization of hydroxypropyl methylcellulose (HPMC) reinforced with HPMC capped copper nanoparticles (HCu NPs) based nanocomposite hydrogel films (NHFs). Spherical nanostructures of HCu NPs (∼40 nm) were achieved by facile precipitation technique using ascorbic acid as a nucleating agent and subsequently made their NHFs via solution casting method. Spectral, thermal and structural characteristics of the developed materials were carried out. Antibacterial activity of the resultant NHFs showed the MIC and MBC values of 350 and 1400 μg/mL for S. aureus, and 500 and 2000 μg/mL for E. coli, respectively. These results conveyed that the HCu NPs incorporated HPMC NHFs can be used effectively in antibacterial applications.
AB - Currently, special emphasis is being given to the design and fabrication of antibacterial nanocomposite hydrogels for wound dressing applications. Herein, we report the synthesis and characterization of hydroxypropyl methylcellulose (HPMC) reinforced with HPMC capped copper nanoparticles (HCu NPs) based nanocomposite hydrogel films (NHFs). Spherical nanostructures of HCu NPs (∼40 nm) were achieved by facile precipitation technique using ascorbic acid as a nucleating agent and subsequently made their NHFs via solution casting method. Spectral, thermal and structural characteristics of the developed materials were carried out. Antibacterial activity of the resultant NHFs showed the MIC and MBC values of 350 and 1400 μg/mL for S. aureus, and 500 and 2000 μg/mL for E. coli, respectively. These results conveyed that the HCu NPs incorporated HPMC NHFs can be used effectively in antibacterial applications.
KW - Antibacterial activity
KW - Hydrogel films
KW - Non-ionic hydroxypropyl methylcellulose
KW - Spherical copper nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85095772369&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2020.117302
DO - 10.1016/j.carbpol.2020.117302
M3 - Article
C2 - 33357869
AN - SCOPUS:85095772369
SN - 0144-8617
VL - 254
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 117302
ER -