How expensive is the astrocyte?

L. F. Barros*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

27 Citas (Scopus)

Resumen

The energy cost of information processing is thought to be chiefly neuronal, with a minor fraction attributed to glial cells. However, there is compelling evidence that astrocytes capture synaptic K+ using their Na+/K+ ATPase, and not solely through Kir4.1 channels as was once thought. When this active buffering is taken into account, the cost of astrocytes rises by >200%. Gram-per-gram, astrocytes turn out to be as expensive as neurons. This conclusion is supported by 3D reconstruction of the neuropil showing similar mitochondrial densities in neurons and astrocytes, by cell-specific transcriptomics and proteomics, and by the rates of the tricarboxylic acid cycle. Possible consequences for reactive astrogliosis and brain disease are discussed.

Idioma originalInglés
Páginas (desde-hasta)738-745
Número de páginas8
PublicaciónJournal of Cerebral Blood Flow and Metabolism
Volumen42
N.º5
DOI
EstadoPublicada - 2022
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© The Author(s) 2022.

Áreas temáticas de ASJC Scopus

  • Neurología
  • Neurología clínica
  • Cardiología y medicina cardiovascular

Huella

Profundice en los temas de investigación de 'How expensive is the astrocyte?'. En conjunto forman una huella única.

Citar esto