Resumen
The energy cost of information processing is thought to be chiefly neuronal, with a minor fraction attributed to glial cells. However, there is compelling evidence that astrocytes capture synaptic K+ using their Na+/K+ ATPase, and not solely through Kir4.1 channels as was once thought. When this active buffering is taken into account, the cost of astrocytes rises by >200%. Gram-per-gram, astrocytes turn out to be as expensive as neurons. This conclusion is supported by 3D reconstruction of the neuropil showing similar mitochondrial densities in neurons and astrocytes, by cell-specific transcriptomics and proteomics, and by the rates of the tricarboxylic acid cycle. Possible consequences for reactive astrogliosis and brain disease are discussed.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 738-745 |
Número de páginas | 8 |
Publicación | Journal of Cerebral Blood Flow and Metabolism |
Volumen | 42 |
N.º | 5 |
DOI | |
Estado | Publicada - 2022 |
Publicado de forma externa | Sí |
Nota bibliográfica
Publisher Copyright:© The Author(s) 2022.
Áreas temáticas de ASJC Scopus
- Neurología
- Neurología clínica
- Cardiología y medicina cardiovascular