TY - JOUR
T1 - Glucose and lactate supply to the synapse
AU - Barros, L. Felipe
AU - Deitmer, Joachim W.
N1 - Funding Information:
We thank Karen Everett for critical reading of the manuscript. This work was supported by a DFG-Conicyt joint grant (to L.F.B. and J.W.D.), by Fondecyt 10070046 to L.F.B and by the Deutsche Forschungsgemeinschaft (DFG), SFB 530 , TP B1 , and 444CHL-113/21/0-1 to J.W. D. The Centro de Estudios Científicos (CECS) is funded by the Chilean Government through the Millennium Science Initiative and the Centers of Excellence Base Financing Program of Conicyt. CECS is also supported by a group of private companies which at present includes Antofagasta Minerals, Arauco, Empresas CMPC, Indura, Naviera Ultragas and Telefónica del Sur. CIN is funded by Conicyt and the Gobierno Regional de Los Ríos.
PY - 2010/5
Y1 - 2010/5
N2 - The main source of energy for the mammalian brain is glucose, and the main sink of energy in the mammalian brain is the neuron, so the conventional view of brain energy metabolism is that glucose is consumed preferentially in neurons. But between glucose and the production of energy are several steps that do not necessarily take place in the same cell. An alternative model has been proposed that states that glucose preferentially taken by astrocytes, is degraded to lactate and then exported into neurons to be oxidized. Short of definitive data, opinions about the relative merits of these competing models are divided, making it a very exciting field of research. Furthermore, growing evidence suggests that lactate acts as a signaling molecule, involved in Na+ sensing, glucosensing, and in coupling neuronal and glial activity to the modulation of vascular tone. In the present review, we discuss possible dynamics of glucose and lactate in excitatory synaptic regions, focusing on the transporters that catalyze the movement of these molecules.
AB - The main source of energy for the mammalian brain is glucose, and the main sink of energy in the mammalian brain is the neuron, so the conventional view of brain energy metabolism is that glucose is consumed preferentially in neurons. But between glucose and the production of energy are several steps that do not necessarily take place in the same cell. An alternative model has been proposed that states that glucose preferentially taken by astrocytes, is degraded to lactate and then exported into neurons to be oxidized. Short of definitive data, opinions about the relative merits of these competing models are divided, making it a very exciting field of research. Furthermore, growing evidence suggests that lactate acts as a signaling molecule, involved in Na+ sensing, glucosensing, and in coupling neuronal and glial activity to the modulation of vascular tone. In the present review, we discuss possible dynamics of glucose and lactate in excitatory synaptic regions, focusing on the transporters that catalyze the movement of these molecules.
KW - Energy
KW - Lactate shuttle
KW - Metabolism
KW - Transport
UR - http://www.scopus.com/inward/record.url?scp=77952394341&partnerID=8YFLogxK
U2 - 10.1016/j.brainresrev.2009.10.002
DO - 10.1016/j.brainresrev.2009.10.002
M3 - Review article
C2 - 19879896
AN - SCOPUS:77952394341
SN - 0165-0173
VL - 63
SP - 149
EP - 159
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 1-2
ER -