TY - JOUR
T1 - Fluid Brain Glycolysis
T2 - Limits, Speed, Location, Moonlighting, and the Fates of Glycogen and Lactate
AU - Barros, L. Felipe
AU - San Martín, Alejandro
AU - Ruminot, Iván
AU - Sandoval, Pamela Y.
AU - Baeza-Lehnert, Felipe
AU - Arce-Molina, Robinson
AU - Rauseo, Daniela
AU - Contreras-Baeza, Yasna
AU - Galaz, Alex
AU - Valdivia, Sharin
N1 - Funding Information:
We thank all past and present members of the Barros Lab for their contributions and discussions. We also thank Karen Everett for critical reading of the manuscript. This work was partially funded by CONICYT-BMBF grant 180045. The Centro de Estudios Cient?ficos (CECs) is funded by the Chilean Government through the Centers of Excellence Basal Financing Program of CONICYT.
Funding Information:
We thank all past and present members of the Barros Lab for their contributions and discussions. We also thank Karen Everett for critical reading of the manuscript. This work was partially funded by CONICYT-BMBF grant 180045. The Centro de Estudios Científicos (CECs) is funded by the Chilean Government through the Centers of Excellence Basal Financing Program of CONICYT.
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Glycolysis is the core of intermediate metabolism, an ancient pathway discovered in the heydays of classic biochemistry. A hundred years later, it remains a matter of active research, clinical interest and is not devoid of controversy. This review examines topical aspects of glycolysis in the brain, a tissue characterized by an extreme dependence on glucose. The limits of glycolysis are reviewed in terms of flux control by glucose transporters, intercellular lactate shuttling and activity-dependent glycolysis in astrocytes and neurons. What is the site of glycogen mobilization and aerobic glycolysis in brain tissue? We scrutinize the pervasive notions that glycolysis is fast and that catalysis is channeled through supramolecular assemblies. In brain tissue, most glycolytic enzymes are catalytically silent.
AB - Glycolysis is the core of intermediate metabolism, an ancient pathway discovered in the heydays of classic biochemistry. A hundred years later, it remains a matter of active research, clinical interest and is not devoid of controversy. This review examines topical aspects of glycolysis in the brain, a tissue characterized by an extreme dependence on glucose. The limits of glycolysis are reviewed in terms of flux control by glucose transporters, intercellular lactate shuttling and activity-dependent glycolysis in astrocytes and neurons. What is the site of glycogen mobilization and aerobic glycolysis in brain tissue? We scrutinize the pervasive notions that glycolysis is fast and that catalysis is channeled through supramolecular assemblies. In brain tissue, most glycolytic enzymes are catalytically silent.
KW - ATP
KW - Astrocyte
KW - Energy
KW - GLUT
KW - Glucose
KW - MCT
KW - Metabolism
KW - Neuron
KW - Pyruvate
UR - http://www.scopus.com/inward/record.url?scp=85081283169&partnerID=8YFLogxK
U2 - 10.1007/s11064-020-03005-2
DO - 10.1007/s11064-020-03005-2
M3 - Article
C2 - 32144525
AN - SCOPUS:85081283169
SN - 0364-3190
VL - 45
SP - 1328
EP - 1334
JO - Neurochemical Research
JF - Neurochemical Research
IS - 6
ER -