Eicosanoids and tumor necrosis factor-alpha in the kidney

Nicholas R. Ferreri*, Shoujin Hao, Paulina L. Pedraza, Bruno Escalante, Carlos P. Vio

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

11 Citas (Scopus)

Resumen

The thick ascending limb of Henle's loop (TAL) is capable of metabolizing arachidonic acid (AA) by cytochrome P450 (CYP450) and cyclooxygenase (COX) pathways and has been identified as a nephron segment that contributes to salt-sensitive hypertension. Previous studies demonstrated a prominent role for CYP450-dependent metabolism of AA to products that inhibited ion transport pathways in the TAL. However, COX-2 is constitutively expressed along all segments of the TAL and is increased in response to diverse stimuli. The ability of Tamm-Horsfall glycoprotein, a selective marker of cortical TAL (cTAL) and medullary (mTAL), to bind TNF and localize it to this nephron segment prompted studies to determine the capacity of mTAL cells to produce TNF and determine its effects on mTAL function. The colocalization of calcium-sensing receptor (CaR) and COX-2 in the TAL supports the notion that activation of CaR induces TNF-dependent COX-2 expression and PGE2 synthesis in mTAL cells. Additional studies showed that TNF produced by mTAL cells inhibits 86Rb uptake, an in vitro correlate of natriuresis, in an autocrine- and COX-2-dependent manner. The molecular mechanism for these effects likely includes inhibition of Na+-K+-2Cl- cotransporter (NKCC2) expression and trafficking.

Idioma originalInglés
Páginas (desde-hasta)101-106
Número de páginas6
PublicaciónProstaglandins and Other Lipid Mediators
Volumen98
N.º3-4
DOI
EstadoPublicada - 2012
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Fisiología
  • Farmacología
  • Biología celular

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