TY - JOUR
T1 - Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)
AU - Guidi, Patrizia
AU - Corsolini, Simonetta
AU - Bernardeschi, Margherita
AU - Rocco, Lucia
AU - Nigro, Marco
AU - Baroni, Davide
AU - Mottola, Filomena
AU - Scarcelli, Vittoria
AU - Santonastaso, Marianna
AU - Falleni, Alessandra
AU - Della Torre, Camilla
AU - Corsi, Ilaria
AU - Pozo, Karla
AU - Frenzilli, Giada
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/1
Y1 - 2018/1
N2 - The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.
AB - The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.
KW - Cytome-Micronucleus assay
KW - DNA damage
KW - PCBs
KW - PCDDs/DFs
KW - RAPD-PCR
KW - TEQs
UR - http://www.scopus.com/inward/record.url?scp=85037367459&partnerID=8YFLogxK
U2 - 10.1016/j.marpolbul.2017.11.062
DO - 10.1016/j.marpolbul.2017.11.062
M3 - Article
C2 - 29421127
AN - SCOPUS:85037367459
SN - 0025-326X
VL - 126
SP - 467
EP - 472
JO - Marine Pollution Bulletin
JF - Marine Pollution Bulletin
ER -