TY - JOUR
T1 - Development of Biocompatible Digital Light Processing Resins for Additive Manufacturing Using Visible Light-Induced RAFT Polymerization
AU - Sarabia-Vallejos, Mauricio A.
AU - De la Fuente, Scarleth Romero
AU - Tapia, Pamela
AU - Cohn-Inostroza, Nicolás A.
AU - Estrada, Manuel
AU - Ortiz-Puerta, David
AU - Rodríguez-Hernández, Juan
AU - González-Henríquez, Carmen M.
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/2
Y1 - 2024/2
N2 - Patients with bone diseases often experience increased bone fragility. When bone injuries exceed the body’s natural healing capacity, they become significant obstacles. The global rise in the aging population and the escalating obesity pandemic are anticipated to lead to a notable increase in acute bone injuries in the coming years. Our research developed a novel DLP resin for 3D printing, utilizing poly(ethylene glycol diacrylate) (PEGDA) and various monomers through the PET-RAFT polymerization method. To enhance the performance of bone scaffolds, triply periodic minimal surfaces (TPMS) were incorporated into the printed structure, promoting porosity and pore interconnectivity without reducing the mechanical resistance of the printed piece. The gyroid TPMS structure was the one that showed the highest mechanical resistance (0.94 ± 0.117 and 1.66 ± 0.240 MPa) for both variants of resin composition. Additionally, bioactive particles were introduced to enhance the material’s biocompatibility, showcasing the potential for incorporating active compounds for specific applications. The inclusion of bioceramic particles produces an increase of 13% in bioactivity signal for osteogenic differentiation (alkaline phosphatase essay) compared to that of control resins. Our findings highlight the substantial improvement in printing precision and resolution achieved by including the photoabsorber, Rose Bengal, in the synthesized resin. This enhancement allows for creating intricately detailed and accurately defined 3D-printed parts. Furthermore, the TPMS gyroid structure significantly enhances the material’s mechanical resistance, while including bioactive compounds significantly boosts the polymeric resin’s biocompatibility and bioactivity (osteogenic differentiation).
AB - Patients with bone diseases often experience increased bone fragility. When bone injuries exceed the body’s natural healing capacity, they become significant obstacles. The global rise in the aging population and the escalating obesity pandemic are anticipated to lead to a notable increase in acute bone injuries in the coming years. Our research developed a novel DLP resin for 3D printing, utilizing poly(ethylene glycol diacrylate) (PEGDA) and various monomers through the PET-RAFT polymerization method. To enhance the performance of bone scaffolds, triply periodic minimal surfaces (TPMS) were incorporated into the printed structure, promoting porosity and pore interconnectivity without reducing the mechanical resistance of the printed piece. The gyroid TPMS structure was the one that showed the highest mechanical resistance (0.94 ± 0.117 and 1.66 ± 0.240 MPa) for both variants of resin composition. Additionally, bioactive particles were introduced to enhance the material’s biocompatibility, showcasing the potential for incorporating active compounds for specific applications. The inclusion of bioceramic particles produces an increase of 13% in bioactivity signal for osteogenic differentiation (alkaline phosphatase essay) compared to that of control resins. Our findings highlight the substantial improvement in printing precision and resolution achieved by including the photoabsorber, Rose Bengal, in the synthesized resin. This enhancement allows for creating intricately detailed and accurately defined 3D-printed parts. Furthermore, the TPMS gyroid structure significantly enhances the material’s mechanical resistance, while including bioactive compounds significantly boosts the polymeric resin’s biocompatibility and bioactivity (osteogenic differentiation).
KW - bioceramics
KW - bone scaffold
KW - DLP resin
KW - photoabsorbers
KW - RAFT polymerization
UR - http://www.scopus.com/inward/record.url?scp=85185723523&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/3438ed0a-f72a-3315-80f6-f2c30b12dd27/
U2 - 10.3390/polym16040472
DO - 10.3390/polym16040472
M3 - Article
AN - SCOPUS:85185723523
SN - 2073-4360
VL - 16
JO - Polymers
JF - Polymers
IS - 4
M1 - 472
ER -