Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)

Luisa Quesada; Margarita Gutierrez; Luis Astudillo; Aurelio San-Martín; Eduardo Fuentes; Iván Palomo; Patricio Peñailillo

Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)

Título traducido de la contribución: Determinación de la actividad antibacteriana, antioxidante, antiagregante plaquetaria e inhibición de la colinesterasa a partir de los extractos metanólicos de especies Azorella (Apiaceae)

Luisa Quesada, Margarita Gutierrez, Luis Astudillo, Aurelio San-Martín, Eduardo Fuentes, Iván Palomo, Patricio Peñailillo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

1 Cita (Scopus)

Resumen

In this study, we investigated the potential antibacterial, antioxidant and anti-platelet activities and the inhibition of cholinesterase from the methanolic extracts obtained from aerial parts of the two species of Azorella: A. spinosa (Constitution, Chile) and A. monantha (Torres del Paine, Enladrillado and Paso Vergara). All extracts showed only moderate inhibitory activity on acetylcholinesterase (AChE), the most active extract with IC50 = 27μg/mL was A. spinosa. Inhibition of platelet aggregation induced by ADP presented maximal aggregation to 70 and 57% on extracts of A. spinosa and A. monantha (Paso Vergara), respectively. The most active extract with antioxidant effect was A. spinosa with IC₅₀ of 28.72μg/mL. Antibacterial activity of the extract on Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii was not present. The extracts of A. spinosa and A. monantha (Paso Vergara) presented the best results on the activities that were evaluated.

Título traducido de la contribución	Determinación de la actividad antibacteriana, antioxidante, antiagregante plaquetaria e inhibición de la colinesterasa a partir de los extractos metanólicos de especies Azorella (Apiaceae)
Idioma original	Inglés
Páginas (desde-hasta)	99-107
Número de páginas	9
Publicación	Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Volumen	12
N.º	1
Estado	Publicada - 2013
Publicado de forma externa	Sí

Áreas temáticas de ASJC Scopus

Descubrimiento de medicamentos
Medicina complementaria y alternativa
Botánica
Farmacología

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{b0cab4097612490d98557079c4a65f04,

title = "Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)",

abstract = "In this study, we investigated the potential antibacterial, antioxidant and anti-platelet activities and the inhibition of cholinesterase from the methanolic extracts obtained from aerial parts of the two species of Azorella: A. spinosa (Constitution, Chile) and A. monantha (Torres del Paine, Enladrillado and Paso Vergara). All extracts showed only moderate inhibitory activity on acetylcholinesterase (AChE), the most active extract with IC50 = 27μg/mL was A. spinosa. Inhibition of platelet aggregation induced by ADP presented maximal aggregation to 70 and 57% on extracts of A. spinosa and A. monantha (Paso Vergara), respectively. The most active extract with antioxidant effect was A. spinosa with IC50 of 28.72μg/mL. Antibacterial activity of the extract on Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii was not present. The extracts of A. spinosa and A. monantha (Paso Vergara) presented the best results on the activities that were evaluated.",

keywords = "Antibacterial, Antioxidant, Antiplatelet, Azorella, Cholinesterase, Total phenolics",

author = "Luisa Quesada and Margarita Gutierrez and Luis Astudillo and Aurelio San-Mart{\'i}n and Eduardo Fuentes and Iv{\'a}n Palomo and Patricio Pe{\~n}ailillo",

year = "2013",

language = "English",

volume = "12",

pages = "99--107",

journal = "Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas",

issn = "0717-7917",

publisher = "MS-Editions",

number = "1",

}

Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae). / Quesada, Luisa; Gutierrez, Margarita; Astudillo, Luis et al.
En: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, Vol. 12, N.º 1, 2013, p. 99-107.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)

AU - Quesada, Luisa

AU - Gutierrez, Margarita

AU - Astudillo, Luis

AU - San-Martín, Aurelio

AU - Fuentes, Eduardo

AU - Palomo, Iván

AU - Peñailillo, Patricio

PY - 2013

Y1 - 2013

N2 - In this study, we investigated the potential antibacterial, antioxidant and anti-platelet activities and the inhibition of cholinesterase from the methanolic extracts obtained from aerial parts of the two species of Azorella: A. spinosa (Constitution, Chile) and A. monantha (Torres del Paine, Enladrillado and Paso Vergara). All extracts showed only moderate inhibitory activity on acetylcholinesterase (AChE), the most active extract with IC50 = 27μg/mL was A. spinosa. Inhibition of platelet aggregation induced by ADP presented maximal aggregation to 70 and 57% on extracts of A. spinosa and A. monantha (Paso Vergara), respectively. The most active extract with antioxidant effect was A. spinosa with IC50 of 28.72μg/mL. Antibacterial activity of the extract on Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii was not present. The extracts of A. spinosa and A. monantha (Paso Vergara) presented the best results on the activities that were evaluated.

AB - In this study, we investigated the potential antibacterial, antioxidant and anti-platelet activities and the inhibition of cholinesterase from the methanolic extracts obtained from aerial parts of the two species of Azorella: A. spinosa (Constitution, Chile) and A. monantha (Torres del Paine, Enladrillado and Paso Vergara). All extracts showed only moderate inhibitory activity on acetylcholinesterase (AChE), the most active extract with IC50 = 27μg/mL was A. spinosa. Inhibition of platelet aggregation induced by ADP presented maximal aggregation to 70 and 57% on extracts of A. spinosa and A. monantha (Paso Vergara), respectively. The most active extract with antioxidant effect was A. spinosa with IC50 of 28.72μg/mL. Antibacterial activity of the extract on Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii was not present. The extracts of A. spinosa and A. monantha (Paso Vergara) presented the best results on the activities that were evaluated.

KW - Antibacterial

KW - Antioxidant

KW - Antiplatelet

KW - Azorella

KW - Cholinesterase

KW - Total phenolics

UR - http://www.scopus.com/inward/record.url?scp=84873189193&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84873189193

SN - 0717-7917

VL - 12

SP - 99

EP - 107

JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

IS - 1

ER -

Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae)

Resumen

Áreas temáticas de ASJC Scopus

Otros archivos y enlaces

Huella

Citar esto