Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

Cristhian Mendoza; George E. Barreto; Alexandre Iarkov; Vadim V. Tarasov; Gjumrakch Aliev; Valentina Echeverria

doi:10.1007/s12035-018-0869-3

Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

Cristhian Mendoza, George E. Barreto, Alexandre Iarkov, Vadim V. Tarasov, Gjumrakch Aliev, Valentina Echeverria^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

17 Citas (Scopus)

Resumen

Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.

Idioma original	Inglés
Páginas (desde-hasta)	6700-6711
Número de páginas	12
Publicación	Molecular Neurobiology
Volumen	55
N.º	8
DOI	https://doi.org/10.1007/s12035-018-0869-3
Estado	Publicada - 2018

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Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Áreas temáticas de ASJC Scopus

Neurología
Neurociencia celular y molecular

ODS de las Naciones Unidas

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title = "Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder",

abstract = "Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.",

keywords = "Cotinine, Extinction, Fear, Inflammation, Nicotinic receptor, Post-traumatic stress disorder",

author = "Cristhian Mendoza and Barreto, {George E.} and Alexandre Iarkov and Tarasov, {Vadim V.} and Gjumrakch Aliev and Valentina Echeverria",

note = "Funding Information: Funding This work was supported by the Fondo de Ciencia y Tecnolog{\'i}a (FONDECYT) de Chile, Grant #1150149. Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Mendoza, Cristhian

AU - Barreto, George E.

AU - Iarkov, Alexandre

AU - Tarasov, Vadim V.

AU - Aliev, Gjumrakch

AU - Echeverria, Valentina

N1 - Funding Information: Funding This work was supported by the Fondo de Ciencia y Tecnología (FONDECYT) de Chile, Grant #1150149. Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2018/8/1

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N2 - Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.

AB - Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.

KW - Cotinine

KW - Extinction

KW - Fear

KW - Inflammation

KW - Nicotinic receptor

KW - Post-traumatic stress disorder

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M3 - Review article

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SN - 0893-7648

VL - 55

SP - 6700

EP - 6711

JO - Molecular Neurobiology

JF - Molecular Neurobiology

IS - 8

ER -

Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

Resumen

Nota bibliográfica

Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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