Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

Carlos P. Vio; Carlos D. Figueroa; Italo Caorsi

doi:10.1093/ajh/1.3.269

Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

Carlos P. Vio^*, Carlos D. Figueroa, Italo Caorsi

^*Autor correspondiente de este trabajo

Pontificia Universidad Católica de Chile

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

55 Citas (Scopus)

Resumen

Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.

Idioma original	Inglés
Páginas (desde-hasta)	269-271
Número de páginas	3
Publicación	American Journal of Hypertension
Volumen	1
N.º	3
DOI	https://doi.org/10.1093/ajh/1.3.269
Estado	Publicada - 1988
Publicado de forma externa	Sí

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Medicina interna

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10.1093/ajh/1.3.269

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title = "Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney",

abstract = "Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.",

keywords = "Human kidney, Juxtaglomerular apparatus, R{\'e}nal kallikrein",

author = "Vio, {Carlos P.} and Figueroa, {Carlos D.} and Italo Caorsi",

note = "Funding Information: Supported by Grants FONDECYT 2047/87, DIUC 202/86, and DID-UACH S 85-38.",

year = "1988",

month = jul,

doi = "10.1093/ajh/1.3.269",

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T1 - Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

AU - Vio, Carlos P.

AU - Figueroa, Carlos D.

AU - Caorsi, Italo

N1 - Funding Information: Supported by Grants FONDECYT 2047/87, DIUC 202/86, and DID-UACH S 85-38.

PY - 1988/7

Y1 - 1988/7

N2 - Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.

AB - Current evidence suggests a functional and biochemical link between the renin and the kallikrein Systems. The purpose of this work was to study the localization of kallikrein along the human nephron to elucidate whethei there exists an anatomical base for such interrelation.Serial sections of human kidney tissue were stained by immunocytochemical methods with antisera against kallikrein. Kallikrein immunostaining was observed ex- clusively in segments of the distal nephron lying in the cortical labyrinths and forming arcades in its distal portion. Consistently the tubules containing kallikrein established a close anatomical relationship with the afferent arteriole of the juxtaglomerular apparatus providing an anatomical base for an interaction between the renin and kallikrein Systems in the human kidney.

KW - Human kidney

KW - Juxtaglomerular apparatus

KW - Rénal kallikrein

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SN - 0895-7061

VL - 1

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EP - 271

JO - American Journal of Hypertension

JF - American Journal of Hypertension

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Anatomical relationship between kallikrein- containing tubules and the juxtaglomerular apparatus in the human kidney

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