Resumen
Aging is the greatest risk factor for neurodegenerative diseases. Microglia are the resident immune cells in the central nervous system (CNS), playing key roles in its normal functioning, and as mediators for age-dependent changes of the CNS, condition at which they generate a hostile environment for neurons. Transforming Growth Factor β1 (TGFβ1) is a regulatory cytokine involved in immuneregulation and neuroprotection, affecting glial cell inflammatory activation, neuronal survival, and function. TGFβ1 signaling undergoes age-dependent changes affecting the regulation of microglial cells and can contribute to the pathophysiology of neurodegenerative diseases. This chapter focuses on assessing the role of age-related changes on the regulation of microglial cells and their impact on neuroinflammation and neuronal function, for understanding age-dependent changes of the nervous system.
| Título traducido de la contribución | La microglia envejecida y su impacto en el sistema nervioso |
|---|---|
| Idioma original | Inglés |
| Título de la publicación alojada | Microglia |
| Subtítulo de la publicación alojada | Physiology, Pathophysiology and Therapeutic Potential |
| Lugar de publicación | Suiza |
| Editorial | Springer Nature |
| Páginas | 379-395 |
| Número de páginas | 17 |
| Volumen | 37 |
| Edición | 1 |
| ISBN (versión digital) | 978-3-031-55529-9 |
| ISBN (versión impresa) | 978-3-031-55528-2 |
| DOI | |
| Estado | Publicada - 2024 |
Serie de la publicación
| Nombre | Advances in Neurobiology |
|---|---|
| Editorial | Springer Nature |
| Volumen | 37 |
| ISSN (versión impresa) | 2190-5215 |
| ISSN (versión digital) | 2190-5223 |
Nota bibliográfica
Publisher Copyright:© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Áreas temáticas de ASJC Scopus
- Bioquímica, genética y biología molecular (todo)
- Neurociencia (todo)