Activity-Dependent Regulation of Glucose Transporters

L. F. Barros*

*Autor correspondiente de este trabajo

Producción científica: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

Resumen

Neuronal activity demands an increase of glucose flux through the blood-brain barrier into the gliovascular unit. The delivery of glucose is controlled by facilitative glucose transporters of the GLUT family, located in the plasma membrane of endothelium, astrocytes, and neurons. Experiments in cultured cells have shown that the neurotransmitter glutamate stimulates the astrocytic glucose transporter GLUT1 and inhibits the neuronal glucose transporter GLUT3, results that support a model in which neuronal activity is preferentially fueled by astrocytic lactate. The predicted modulation of endothelial glucose transport by neuronal activity remains to be discovered.

Idioma originalInglés
Título de la publicación alojadaEncyclopedia of Neuroscience
EditorialElsevier Ltd
Páginas61-65
Número de páginas5
ISBN (versión impresa)9780080450469
DOI
EstadoPublicada - 2009
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Neurociencias General

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