TY - JOUR
T1 - A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus
T2 - Launching the GLADEL 2.0 Study Group
AU - Gladel CO-authors
AU - Gómez-Puerta, José A.
AU - Pons-Estel, Guillermo J.
AU - Quintana, Rosana
AU - Nieto, Romina
AU - Serrano Morales, Rosa M.
AU - Harvey, Guillermina B.
AU - Wojdyla, Daniel
AU - Scolnik, Marina
AU - Funes Soaje, Carmen
AU - Alba Moreyra, Paula
AU - Novatti, Elisa
AU - Arizpe, Fernando
AU - Berbotto, Guillermo A.
AU - González Lucero, Luciana
AU - Porta, Sabrina
AU - Pérez, Nicolás
AU - Rodriguez, Anabella M.
AU - Appenzeller, Simone
AU - de Oliveira e Silva Montadon, Ana Carolina
AU - Monticielo, Odirlei Andre
AU - Cavalcanti, Fernando S.
AU - Machado Ribeiro, Francinne
AU - Borba, Eduardo F.
AU - Torres dos Reis-Neto, Edgard
AU - Neira, Oscar
AU - Chahuán, José Miguel
AU - Mimica, Milena
AU - Aroca Martínez, Gustavo
AU - Tobón, Gabriel J.
AU - Vásquez, Gloria
AU - Quintana-Lopez, Gerardo
AU - Moreno Alvarez, Mario J.
AU - Saavedra, Miguel Ángel
AU - Cristobal, Mario Pérez
AU - Fragoso-Loyo, Hilda
AU - Amezcua-Guerra, Luis M.
AU - González-Bello, Yelitza C.
AU - Abud-Mendoza, Carlos
AU - Esquivel-Valerio, Jorge A.
AU - Duarte, Margarita
AU - Acosta Colman, Isabel
AU - Mora-Trujillo, Claudia
AU - Reátegui-Sokolova, Cristina
AU - Calvo Quiroz, Armando A.
AU - Muñoz-Louis, Roberto
AU - Cairoli, Ernesto
AU - Rosas, Iliana
AU - Rebella, Martín
AU - Cardiel, Mario H.
AU - Massardo, Loreto
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/4
Y1 - 2021/4
N2 - Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
AB - Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
KW - Latin American
KW - Lupus
KW - biomarkers
KW - lupus nephritis
KW - multiethnic
UR - http://www.scopus.com/inward/record.url?scp=85100631536&partnerID=8YFLogxK
U2 - 10.1177/0961203320988586
DO - 10.1177/0961203320988586
M3 - Article
C2 - 33509067
AN - SCOPUS:85100631536
SN - 0961-2033
VL - 30
SP - 630
EP - 640
JO - Lupus
JF - Lupus
IS - 4
ER -