TY - JOUR
T1 - 5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications
AU - Jayaramudu, Tippabattini
AU - Raghavendra, Gownolla Malegowd
AU - Varaprasad, Kokkarachedu
AU - Raju, Konduru Mohana
AU - Sadiku, Emmanuel Rotimi
AU - Kim, Jaehwan
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (contract grant number NRF-2015R1A3A2066301) and the author Kokkarachedu Varaprasad wishes to acknowledge the Programa de Atracción e Inserciun de Capital Humano Avanzado (PAI) Proyecto No. 781302011, CONICYT, Chile and the CIPA, CONICYT Regional PRFC0002.
Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/10/5
Y1 - 2016/10/5
N2 - For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy.
AB - For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy.
KW - biocompatibility
KW - biomedical applications
KW - drug-delivery systems
KW - gels
KW - hydrophilic polymers
UR - http://www.scopus.com/inward/record.url?scp=84973452246&partnerID=8YFLogxK
U2 - 10.1002/app.43921
DO - 10.1002/app.43921
M3 - Article
AN - SCOPUS:84973452246
SN - 0021-8995
VL - 133
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 37
M1 - APP43921
ER -