Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Pierre Bourdely; Giorgio Anselmi; Kristine Vaivode; Rodrigo Nalio Ramos; Yoann Missolo-Koussou; Sofia Hidalgo; Jimena Tosselo; Nicolas Nuñez; Wilfrid Richer; Anne Vincent-Salomon; Alka Saxena; Kristie Wood; Alvaro Lladser; Eliane Piaggio; Julie Helft; Pierre Guermonprez

doi:10.1016/j.immuni.2020.06.002

Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells

Pierre Bourdely, Giorgio Anselmi, Kristine Vaivode, Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Sofia Hidalgo, Jimena Tosselo, Nicolas Nuñez, Wilfrid Richer, Anne Vincent-Salomon, Alka Saxena, Kristie Wood, Alvaro Lladser, Eliane Piaggio, Julie Helft, Pierre Guermonprez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Abstract

Bourdely et al. identify human CD88⁻CD1c⁺CD163⁺ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103⁺CD8⁺ T cells in vitro, and their infiltration correlates with CD8⁺CD69⁺CD103⁺ T_RM accumulation in breast tumors.

Original language	English
Pages (from-to)	335-352.e8
Journal	Immunity
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2020.06.002
State	Published - 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.immuni.2020.06.002

Cite this

Bourdely, P., Anselmi, G., Vaivode, K., Ramos, R. N., Missolo-Koussou, Y., Hidalgo, S., Tosselo, J., Nuñez, N., Richer, W., Vincent-Salomon, A., Saxena, A., Wood, K., Lladser, A., Piaggio, E., Helft, J., & Guermonprez, P. (2020). Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells. Immunity, 53(2), 335-352.e8. https://doi.org/10.1016/j.immuni.2020.06.002

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title = "Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells",

abstract = "Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro, and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.",

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author = "Pierre Bourdely and Giorgio Anselmi and Kristine Vaivode and Ramos, {Rodrigo Nalio} and Yoann Missolo-Koussou and Sofia Hidalgo and Jimena Tosselo and Nicolas Nu{\~n}ez and Wilfrid Richer and Anne Vincent-Salomon and Alka Saxena and Kristie Wood and Alvaro Lladser and Eliane Piaggio and Julie Helft and Pierre Guermonprez",

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doi = "10.1016/j.immuni.2020.06.002",

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Bourdely, P, Anselmi, G, Vaivode, K, Ramos, RN, Missolo-Koussou, Y, Hidalgo, S, Tosselo, J, Nuñez, N, Richer, W, Vincent-Salomon, A, Saxena, A, Wood, K, Lladser, A, Piaggio, E, Helft, J & Guermonprez, P 2020, 'Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells', Immunity, vol. 53, no. 2, pp. 335-352.e8. https://doi.org/10.1016/j.immuni.2020.06.002

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AU - Bourdely, Pierre

AU - Anselmi, Giorgio

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AU - Ramos, Rodrigo Nalio

AU - Missolo-Koussou, Yoann

AU - Hidalgo, Sofia

AU - Tosselo, Jimena

AU - Nuñez, Nicolas

AU - Richer, Wilfrid

AU - Vincent-Salomon, Anne

AU - Saxena, Alka

AU - Wood, Kristie

AU - Lladser, Alvaro

AU - Piaggio, Eliane

AU - Helft, Julie

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KW - DC3s

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